THE INFLUENCE OF ANTIBIOTICS ON THE IMMUNE-SYSTEM - IMMUNO-PHARMACOKINETIC INVESTIGATIONS ON THE PRIMARY ANTI-SRBC RESPONSE IN CARP, CYPRINUS-CARPIO L, AFTER OXYTETRACYCLINE INJECTION
THE INFLUENCE OF ANTIBIOTICS ON THE IMMUNE-SYSTEM - IMMUNO-PHARMACOKINETIC INVESTIGATIONS ON THE PRIMARY ANTI-SRBC RESPONSE IN CARP, CYPRINUS-CARPIO L, AFTER OXYTETRACYCLINE INJECTION
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DOI：
10.1111/j.1365-2761.1987.tb00716.x
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发表时间：
1987-01-01
影响因子：
2.5
通讯作者：
VANMUISWINKEL, WB
中科院分区：
文献类型：
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作者：
GRONDEL, JL;NOUWS, JFM;VANMUISWINKEL, WB
本研究的目的是为了进一步了解土霉素 (OTC) 对鲤鱼 (Cyprinus carpio L) 的免疫调节作用。通过研究 OTC 的药代动力学行为，扩展了免疫学研究。土霉素，剂量60mg/kg，腹腔注射5次，间隔3天；第一次注射是在免疫前1天进行的。在短期 OTC 治疗期间，初级抗绵羊红细胞 (SRBC) 反应的动力学表明，空斑形成细胞 (PFC) 反应的动力学不受 OTC 及其溶剂的显着影响。相反，斑块形成细胞的数量显着减少。两个实验组（OTC 和溶剂）的抗 SRBC 抗体产生均延迟 2-4 天。然而，在免疫后12-14天内，检测到与对照组相同的抗体水平。单次腹腔注射后约 10 小时检测到高 OTC 血浆水平（> 50 μg/ml）。注射。计算出平均血浆消除半衰期（T1/2 为 34.5 小时）。
The present study was performed to obtain further details on the immunomodulating effects of oxytetracycline (OTC) in carp, Cyprinus carpio L. The immunological study was extended by investigating the pharmacokinetic behaviour of OTC. Oxytetracycline, at a dosage of 60 mg/kg, was administered five times intraperitoneally at 3-day intervals; the first injection was given 1 day before immunization. The kinetics of the primary anti-sheep red blood cell (SRBC) response, during a short-term OTC treatment revealed that the kinetics of the plaque-forming cell (PFC) response was not significantly affected by OTC nor its solvent. In contrast, the number of plaque-forming cells was significantly decreased. The anti-SRBC antibody production was delayed by 2-4 days in both experimental groups (OTC and solvent). However, within 12-14 days post-immunization, the same antibody levels were detected as in the control group. High OTC plasma levels (> 50 .mu.g/ml) were detected about 10 h after a single i.p. injection. A mean plasma elimination half-life (T1/2 of 34.5 h was calculated.