Pertussis outbreak on a neonatal unit: identification of a healthcare worker as the likely source
Pertussis outbreak on a neonatal unit: identification of a healthcare worker as the likely source
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DOI：
10.1016/j.jhin.2008.02.011
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发表时间：
2008-06-01
影响因子：
6.9
通讯作者：
Klein, J. L.
中科院分区：
文献类型：
--
作者：
Alexander, E. M.;Travis, S.;Klein, J. L.
我们描述的调查和遏制百日咳爆发的新生儿单位。采用细菌培养、聚合酶链反应（PCR）和血清学方法对疑似病例进行确诊。确认了两名患有百日咳的婴儿，并追踪了一名长时间咳嗽的护士作为可能的传染源。控制干预措施包括卫生保健工作者和患者的大规模化学预防，以及咳嗽的卫生保健工作者被排除在工作之外。聚合酶链反应的使用可以快速评估疫情的程度。这次暴发突出了百日咳博德泰拉在年轻成人中传播对住院婴儿造成的风险，并说明了PCR在快速评估暴发程度方面的效用。预防策略，如青少年普遍接种疫苗，或选择性接种卫生保健工作者，应考虑在英国。(C) 2008年医院，感染学会。Elsevier Ltd.出版。版权所有。
We describe the investigation and containment of an outbreak of pertussis on a neonatal unit. Bacterial culture, polymerase chain reaction (PCR) and serology were used to confirm suspected cases. Two infants with pertussis were identified and a nurse with prolonged cough was traced as the likely source. Control interventions included mass chemoprophylaxis of healthcare workers and patients and exclusion from work of healthcare workers with cough. The use of PCR allowed rapid assessment of the extent of the outbreak. This outbreak highlights the risk to hospitalised infants posed by circulation of Bordetella pertussis in young adults and illustrates the utility of PCR in rapidly assessing the extent of outbreaks. Prevention strategies such as universal vaccination of adolescents, or selective vaccination of healthcare workers, should be considered in the UK. (C) 2008 The Hospital, Infection Society. Published by Elsevier Ltd. All rights reserved.