Relationship Between Decrease of Oxygenation During Incremental Exercise and Partial Pressure End-Tidal Carbon Dioxide: Near-Infrared Spectroscopy Vector Analysis
Relationship Between Decrease of Oxygenation During Incremental Exercise and Partial Pressure End-Tidal Carbon Dioxide: Near-Infrared Spectroscopy Vector Analysis
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DOI：
10.1007/978-3-030-48238-1_19
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发表时间：
2021-01-01
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影响因子：
--
通讯作者：
Tsubaki, Atsuhiro
中科院分区：
文献类型：
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作者：
Kojima, Sho;Morishita, Shinichiro;Tsubaki, Atsuhiro
以往的研究认为，在递增负荷运动中，最大运动前即刻脑氧合血红蛋白（O（2）Hb）的降低与脑血流量（CBF）和呼气末二氧化碳分压（PETCO 2）有关。本研究应用向量分析法探讨O（2）Hb、PETCO 2与脑血容量（CBV）估计值和脑氧交换（COE）之间的关系。24名健康的年轻男性参与了这项研究。他们在休息和热身4分钟后进行递增运动（20 W/min）。采用近红外光谱法（NIRS）测定前额叶皮层（PFC）氧合血红蛋白（O2 Hb）和脱氧血红蛋白（HHb）含量。使用气体分析仪测量PETCO 2。O（2）Hb、HHb和PETCO 2计算为平均4分钟休息后的变化量（Δ O（2）Hb、Δ HHb和Δ PETCO 2）。使用NIRS矢量分析估计CBV（Δ CBV）和COE（Δ COE）的变化。此外，还检测到与O（2）Hb下降相关的呼吸补偿点（RCP）。Pearson相关系数用于建立从RCP到最大运动的Delta O2 Hb、Delta PETCO 2、Delta CBV和Delta COE之间的关系。Delta PETCO 2与Delta O（2）Hb（r = 0.03，p = 0.88）、Delta COE（r =-0.19，p = 0.36）和Delta CBV（r =-0.21，p = 0.31）无显著相关性。这些结果表明，从RCP到最大运动的Δ PETCO 2变化与Δ O（2）Hb、Δ COE和Δ CBV的变化无关。因此，我们认为，在递增负荷运动中，最大运动前即刻O（2）Hb的降低可能与神经活动增加引起的脑氧代谢有关，而与PETCO 2引起的CBF降低无关。
A previous study considered that a decrease in cerebral oxyhemoglobin (O(2)Hb) immediately before maximal exercise during incremental exercise is related to cerebral blood flow (CBF) and partial pressure end-tidal carbon dioxide (PETCO2). This study aimed to investigate the relationship between O(2)Hb, PETCO2, and the estimated value of cerebral blood volume (CBV) with cerebral oxygen exchange (COE) by using vector analysis. Twenty-four healthy young men participated in this study. They performed the incremental exercise (20 W/min) after a 4-min rest and warm-up. The O(2)Hb and deoxyhemoglobin (HHb) in the prefrontal cortex (PFC) were measured using near-infrared spectroscopy (NIRS). The PETCO2 was measured using a gas analyzer. The O(2)Hb, HHb, and PETCO2 were calculated as the amount of change (Delta O(2)Hb, Delta HHb, and Delta PETCO2) from an average 4-min rest. Changes in the CBV (Delta CBV) and COE (Delta COE) were estimated using NIRS vector analysis. Moreover, the respiratory compensation point (RCP), which relates to the O(2)Hb decline, was detected. The Pearson correlation coefficient was used to establish the relationships among Delta O2Hb, Delta PETCO2, Delta CBV, and Delta COE from the RCP to maximal exercise. The Delta PETCO2 did not significantly correlate with the Delta O(2)Hb (r = 0.03, p = 0.88), Delta COE (r = -0.19, p = 0.36), and Delta CBV (r = -0.21, p = 0.31). These results showed that changes in the Delta PETCO2 from the RCP to maximal exercise were not related to changes in the Delta O(2)Hb, Delta COE, and Delta CBV. Therefore, we suggested that the decrease of O(2)Hb immediately before maximal exercise during incremental exercise may be related to cerebral oxygen metabolism by neural activity increase, not decrease of CBF by the PETCO2.