Endogenous retroviruses transcriptomes in response to four avian pathogenic microorganisms infection in chicken
Endogenous retroviruses transcriptomes in response to four avian pathogenic microorganisms infection in chicken
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DOI：
10.1016/j.ygeno.2022.110371
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发表时间：
2022-05-04
期刊：
影响因子：
4.4
通讯作者：
Zhang，Xiquan
中科院分区：
文献类型：
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作者：
Dai，Manman;Xie，Tingting;Zhang，Xiquan
内源性逆转录病毒（ERVs）对鸡疾病的影响尚不清楚。在这里，我们系统地从鸡基因组中鉴定出436个相对完整的cherv。随后，对J亚群禽白血病病毒（ALV-J）、禽流感病毒（AIV）、马立克氏病病毒（MDV）和禽致病性大肠杆菌（APEC）感染后的鸡进行ChERV转录组分析。我们发现，在感染和未感染的样本中，约50%-68%的cherv具有转录活性，尽管大多数cherv的丰度相对较低。此外，与未感染的样本相比，ALV-J、AIV、MDV和APEC感染样本中分别有49、18、66和17个cherv表达显著差异。这些发现可能对了解cherv在应对病原微生物感染中的作用和功能具有重要意义。
The impact of Endogenous retroviruses (ERVs) on chicken disease is not well understood. Here, we systematically identified 436 relatively complete ChERVs from the chicken genome. Subsequently, ChERV transcriptomes were analyzed in chicken after subgroup J avian leukosis virus (ALV-J), avian influenza virus (AIV), Marek's disease virus (MDV) and avian pathogenicEscherichia coli(APEC) infection. We found that about 50%–68% of ChERVs were transcriptionally active in infected and uninfected-samples, although the abundance of most ChERVs is relatively low. Moreover, compared to uninfected-samples, 49, 18, 66 and 17 ChERVs were significantly differentially expressed in ALV-J, AIV, MDV and APEC infected-samples, respectively. These findings may be of significance for understanding the role and function of ChERVs to response the pathogenic microorganism infection.