THERMAL-INJURY TO BONE - A VITAL-MICROSCOPIC DESCRIPTION OF HEAT-EFFECTS
THERMAL-INJURY TO BONE - A VITAL-MICROSCOPIC DESCRIPTION OF HEAT-EFFECTS
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DOI：
10.1016/s0300-9785(82)80020-3
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发表时间：
1982-01-01
期刊：
影响因子：
--
通讯作者：
MCQUEEN, D
中科院分区：
文献类型：
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作者：
ERIKSSON, A;ALBREKTSSON, T;MCQUEEN, D
描述了一种钛植入物，热室，允许在加热和骨温度测量期间同时进行骨组织的重要显微镜观察。可在载玻片和电影胶片上跟踪和记录对确定的热创伤的组织反应。热室技术允许在不确定的随访期内重复观察相同的骨组织隔室。在本实验中，将该室插入兔胫骨中并加热至53 ℃。在加热至指定温度期间，血流速度最初增加。在53度。C，血流在一些血管中停止，在另一些血管中变得缓慢。加热后两天，原有血管中的血流停止。所有原始血管都被向内生长的新血管通路所取代。烧伤后3-5周，烧伤前脂肪细胞被吸收，骨重建开始。温度为53度。C，即，在碱性磷酸酶的变性点以下，引起不可逆的骨损伤，之后从周围组织发生标记。
A Ti implant, the thermal chamber, allowing vital microscopic observations of bone tissue during heating and bone temperature measurements to be made simultaneously is described. The tissue reactions to a defined heat trauma may be followed and registered on slides and cine film. The thermal chamber technique allows repeated observations of the same bone tissue compartment for indefinite follow-up periods. In the present experiment, the chamber was inserted in the rabbit tibia and heating to 53.degree. C was applied for 1 min. During heating to the assigned temperature, the blood-flow velocity initially increased. At 53.degree. C, the blood flow stopped in some vessels and became sluggish in others. Two days after heating, the blood flow in the pre-existing vessels had stopped. All original vessels became replaced with ingrowing newly-developed vascular pathways. Fat cells seen before burning became resorbed and bone remodeling started 3-5 wk after the heat injury. A temperature of 53.degree. C, i.e., below the denaturation point of alkaline phosphatase, caused an irreversible bone injury, after which labeling occurred from the surrounding tissues.