Echium oil is better than rapeseed oil in improving the response of barramundi to a disease challenge
Echium oil is better than rapeseed oil in improving the response of barramundi to a disease challenge
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DOI：
10.1016/j.foodchem.2013.04.052
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发表时间：
2013-11-15
期刊：
影响因子：
8.8
通讯作者：
Carter, Chris G.
中科院分区：
文献类型：
--
作者：
Alhazzaa, Ramez;Bridle, Andrew R.;Carter, Chris G.
病原体感染刺激脂肪酸 (FA) 代谢和 FA 促炎衍生物的产生。尖吻鲈 (Barramundi, Lates calcarifer) 饲喂富含来自鱼油 (FO) 的预制长链 (>= C-20) 多不饱和脂肪酸 (LC-PUFA) 的饮食，与含有高水平 LC-PUFA 的 C-18 前体（十八碳四烯酸 (SDA) 和 γ-亚麻酸 (GLA)）的饮食进行比较，这些前体来自蓝蓟 (EO) 或富含α-亚麻酸 (ALA)，但 LC-PUFA 及其前体的不良来源。 6周后，当饮食治疗中的生长率相似时，对一半的鱼施用亚致死剂量的海豚链球菌，而另一半则保持不受攻击，并与受感染的鱼配对喂养。在疾病挑战情况下，组织 FA 库在感染后 3 天 (DPI) 时耗尽，然后在 7 DPI 时恢复到之前的浓度。在感染期间，与RO鱼相比，EO鱼组织中n3和n6 PUFA含量较高，n3:n6 PUFA比例较高，血浆中类花生酸、TXB2和6-keto-PGF(1α)水平降低。与饲喂 RO 的鱼相比，饲喂 FO 和 EO 的鱼在细菌感染一周后，其 FA 和类二十烷酸浓度的反应更持久。事实证明，含有 SDA 和 GLA 且 n3:n6 PUFA 比例相对较高的 EO 在补偿免疫应激方面比 RO 更有效。 (C) 2013 Elsevier Ltd. 保留所有权利。
Pathogen infection stimulates the fatty acid (FA) metabolism and the production of pro-inflammatory derivatives of FA. Barramundi, Lates calcarifer, was fed on a diet rich in preformed long-chain (>= C-20) polyunsaturated fatty acids (LC-PUFA) from fish oil (FO), to compare with diets containing high levels of C-18 precursors for LC-PUFA - stearidonic (SDA) and gamma-linolenic acid (GLA) - from Echium plantagineum (EO), or rapeseed oil (RO) rich in alpha-linolenic acid (ALA), but a poor source of LC-PUFA and their precursors. After 6 weeks, when growth rates were similar amongst the dietary treatments, a sub-lethal dose of Streptococcus iniae was administered to half of the fish, while the other half were maintained unchallenged and were pair-fed with the infected fish. Under a disease challenge situation, the tissue FA depots depleted at 3 days post-infection (DPI) and were then restored to their previous concentrations at 7 DPI. During the infection period, EO fish had a higher content of n3 and n6 PUFA in their tissues, higher n3:n6 PUFA ratio and reduced levels of the eicosanoids, TXB2 and 6-keto-PGF(1 alpha), in their plasma compared with RO fish. Fish fed on FO and EO had a longer lasting and enduring response in their FA and eicosanoid concentrations, following a week of bacterial infection, compared with those fed on RO. EO, containing SDA and GLA and with a comparatively higher n3:n6 PUFA ratio, proved more effective than RO in compensating for immunity stress. (C) 2013 Elsevier Ltd. All rights reserved.