Vagus nerve stimulation during rehabilitative training improves forelimb strength following ischemic stroke
Vagus nerve stimulation during rehabilitative training improves forelimb strength following ischemic stroke
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DOI：
10.1016/j.nbd.2013.08.002
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发表时间：
2013-12-01
影响因子：
6.1
通讯作者：
Kilgard, M. P.
中科院分区：
文献类型：
--
作者：
Khodaparast, N.;Hays, S. A.;Kilgard, M. P.
上肢损伤是缺血性卒中常见的衰弱性后果。中风后的身体康复可以增强神经可塑性，改善肢体功能，但通常不能恢复正常的运动。我们最近开发了一种新的方法，使用迷走神经刺激（VNS）与前肢运动配对，以驱动特定的，持久的地图可塑性在大鼠初级运动皮层。在这里，我们报告，迷走神经刺激与康复训练配对可以促进大鼠初级运动皮层梗死后前肢力量产生的恢复。在康复训练期间给予VNS时，前肢功能的定量测量恢复到病变前水平。没有迷走神经刺激的强化康复训练未能将功能恢复到病变前水平。在康复期间接受VNS的动物比接受相同康复但没有VNS的大鼠改善两倍。在物理康复期间提供VNS是一种新的方法，可以为中风恢复提供持久的益处。(C)2013 Elsevier Inc. All rights reserved.
Upper limb impairment is a common debilitating consequence of ischemic stroke. Physical rehabilitation after stroke enhances neuroplasticity and improves limb function, but does not typically restore normal movement. We have recently developed a novel method that uses vagus nerve stimulation (VNS) paired with forelimb movements to drive specific, long-lasting map plasticity in rat primary motor cortex. Here we report that VNS paired with rehabilitative training can enhance recovery of forelimb force generation following infarction of primary motor cortex in rats. Quantitative measures of forelimb function returned to pre-lesion levels when VNS was delivered during rehab training. Intensive rehab training without VNS failed to restore function back to pre-lesion levels. Animals that received VNS during rehab improved twice as much as rats that received the same rehabilitation without VNS. VNS delivered during physical rehabilitation represents a novel method that may provide long-lasting benefits towards stroke recovery. (C) 2013 Elsevier Inc. All rights reserved.