Eastern Equine Encephalitis in Children, Massachusetts and New Hampshire, USA, 1970-2010
Eastern Equine Encephalitis in Children, Massachusetts and New Hampshire, USA, 1970-2010
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DOI：
10.3201/eid1902.120039
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发表时间：
2013-02-01
影响因子：
11.8
通讯作者：
Ahmed, Asim A.
中科院分区：
文献类型：
--
作者：
Silverman, Michael A.;Misasi, John;Ahmed, Asim A.
我们描述了1970-2010年间15例儿童东部马脑炎的临床、实验室和放射学特征。最常见的临床和实验室特征是发热、头痛、癫痫发作、外周血白细胞增多和脑脊液嗜中性粒细胞增多症。在基底节区、丘脑和大脑皮层发现影像学病变：临床结果包括5例（33%）患者出现严重神经功能缺损，4例（27%）患者死亡，4例（27%）患者完全恢复，2例（13%）患者出现轻度神经功能缺损。我们确定了短前驱症状与死亡或严重疾病风险增加之间的关联。
We describe the clinical, laboratory, and radiographic characteristics of 15 cases of eastern equine encephalitis in children during 1970-2010. The most common clinical and laboratory features were fever, headache, seizures, peripheral leukocytosis, and cerebrospinal fluid neutrophilic pleocytosis. Radiographic lesions were found in the basal ganglia, thalami, and cerebral cortex: Clinical outcomes included severe neurologic deficits in 5 (33%) patients, death of 4 (27%), full recovery of 4 (27%), and mild neurologic deficits in 2 (13%). We identify an association between a short prodrome and an increased risk for death or for severe disease.