Diurnal profile of plasma motilin concentrations during fasting and feeding in man
Diurnal profile of plasma motilin concentrations during fasting and feeding in man
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人类禁食和进食期间血浆胃动素浓度的昼夜变化
DOI：
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发表时间：
1985
期刊：
影响因子：
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通讯作者：
A. Vinik
中科院分区：
文献类型：
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作者：
A. Funakoshi;L. L. Ho;K. C. Jen;R. Knopf;A. Vinik
概述胰腺激素、胰岛素、胰高血糖素和胰多肽的基础血浆水平的振荡先前已有报道。我们现在报告的振荡循环胃动素样免疫反应（MLI）在空腹和fed man.6健康受试者进行了研究，在两个36小时的测试期间，一个，而空腹和另一个定期摄入equicaloric餐在0800，1200和1800小时。从0800至2400每30分钟采集一次血样，从2400至次日早晨0800每60分钟采集一次血样。在空腹状态下，平均值±S.E. 6名受试者的血浆浓度为：MLI，180 ±19.4 pg/ml，胰岛素4.4 ±1.1 μ/U/ml，胰多肽（hpp），119 ±25.0 pg/ml，葡萄糖82 ±6.4 mg/dl。检测到血浆MLI的大振荡，振幅为平均值的23.2 ±4.7%，周期为159分钟，根据每个受试者而变化。血浆hpp水平波动相似，并且在MLI和hPP之间发现了良好的相关性，表明这些肽由肠道和胰腺有节奏地分泌。MLI的波动是独立的胰岛素，揭示了一个显着的振荡期为320分钟。膳食的摄入引起预期的胰岛素，hPP和葡萄糖的循环水平的增加。相反，观察到MLI浓度降低。MLI与血糖、胰岛素呈负相关。因此，禁食与胃动素（肠道运动激素）的大幅波动有关，而进食则抑制胃动素的波动。葡萄糖和/或胰岛素的增加可能在进食期间抑制胃动素分泌方面是重要的。
SummaryOscillations in basal plasma levels of the pancreatic hormones; insulin, glucagon and pancreatic polypeptide have been reported previously. We now report on oscillations in circulating motilin-like immunoreactivity (MLI) in fasted and fed man. Six healthy subjects were studied during two 36-hour test periods, one while fasting and another with the regular ingestion of equicaloric meals at 0800, 1200 and 1800 hours. Blood was sampled every 30 min. from 0800 to 2400 and every 60 min. from 2400 to 0800 the next morning. In the fasting state the mean ±S.E. concentrations in plasma for the 6 subjects were: MLI, 180 ±19.4 pg/ml, insulin 4.4 ±1.1 μ/U/ml, pancreatic polypeptide (hpp), 119 ±25.0 pg/ml, and glucose 82 ±6.4 mg/dl. Large oscillations in plasma MLI were detected with 1/2 amplitude of 23.2 ±4.7% of mean, and a period of 159 min. which varied according to each subject. Plasma hpp levels fluctuated similarly, and a good correlation was found between MLI and hPP indicating a rhythmic secretion of these peptides by the gut and pancreas. MLI fluctuations were independent of insulin which revealed a significant oscillation with a period of 320 min.The ingestion of meals caused the expected increase in circulating levels of insulin, hPP, and glucose. In contrast a decrease in the concentration of MLI was observed. An inverse correlation was found between MLI and glucose and between MLI and insulin. Thus, fasting is associated with large oscillations of motilin, the gut motility hormone, which are suppressed by feeding. The increase in glucose and/or insulin may be important in suppressing motilin secretion during feeding.