THE DIVERSITY OF NEUROLOGIC EVENTS IN SYSTEMIC LUPUS-ERYTHEMATOSUS - PROSPECTIVE CLINICAL AND COMPUTED TOMOGRAPHIC CLASSIFICATION OF 82 EVENTS IN 71 PATIENTS
THE DIVERSITY OF NEUROLOGIC EVENTS IN SYSTEMIC LUPUS-ERYTHEMATOSUS - PROSPECTIVE CLINICAL AND COMPUTED TOMOGRAPHIC CLASSIFICATION OF 82 EVENTS IN 71 PATIENTS
复制标题
DOI：
10.1001/archneur.1986.00520030063016
复制
发表时间：
1986-03-01
影响因子：
--
通讯作者：
LOCKSHIN, MD
中科院分区：
文献类型：
--
作者：
KAELL, AT;SHETTY, M;LOCKSHIN, MD
为了研究中枢神经系统性红斑狼疮（SLE）的结局和病理生理学，我们前瞻性地收集了所有CNS SLE病例。71例患者发生82起事件。4例患者发生的4起事件是由于感染所致，因此被排除。11例抗核抗体阳性而抗DNA抗体阴性，无其他SLE表现的患者发生了12例SLE事件。在其余66起事件（56例患者）中，26起事件为“孤立”事件，40起为“复杂”事件。非中枢神经系统性红斑狼疮在47起事件中为“活动性”，在19起事件中为“非活动性”。“孤立的”CNS事件在临床“活动性”和“非活动性”SLE中的可能性相等。活动性SLE患者与非活动性SLE患者一样可能有间歇性或缓解性病程。然而，“复杂”事件比“孤立”事件更有可能产生有利的结局。没有局灶性CT异常的“孤立”事件，是CNS SLE中唯一可以称为弥漫性狼疮脑炎的成分，仅占所有神经系统事件的20%。
To investigate outcome and pathophysiology of central nervous system (CNS) systemic lupus erythematosus (SLE), we prospectively codified all cases of CNS SLE. Eighty-two events occurred in 71 patients. Four events in four patients were due to infection and were excluded. Twelve events occurred in 11 women with positive antinuclear antibody but negative anti-DNA antibody test reactions and no other manifestation of SLE. Of the remaining 66 events (56 patients), 26 events were "isolated" and 40 "complex". Non-CNS SLE was "active" during 47 events and "inactive" druing 19 events. "Isolated" CNS events were equally likely in clinically "active" and "inactive" SLE. Patients with active SLE were as likely to have an episodic or remittent course as were patients with inactive SLE. "Complex" events, however, were more likely to have favorable outcome than were "isolated" events. "Isolated" events without focal CT abnormalities, the only component of CNS SLE that can be called diffuse lupus encephalitis, accounted for only 20% of all neurologic events.