Lysine Crotonylation: An Emerging Player in DNA Damage Response.
Lysine Crotonylation: An Emerging Player in DNA Damage Response.
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DOI：
10.3390/biom12101428
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发表时间：
2022-10-05
期刊：
影响因子：
5.5
通讯作者：
中科院分区：
文献类型：
--
作者：
DNA损伤反应(DDR)系统在维持基因组稳定和预防相关疾病方面发挥着重要作用。DDR网络由许多蛋白质和蛋白质的翻译后修饰(PTM)组成，它们以协调的方式工作，以抵消各种遗传毒性应激。赖氨酸巴豆化(KCR)是一种新发现的PTM，存在于各种生物体的核心组蛋白和非组蛋白中。这种新型的PTM被归类为可逆酰化修饰，它受多种酰基酶和脱酰基酶以及细胞内巴豆酰-辅酶A底物浓度的调节。最近的研究表明，KCR将细胞代谢与基因调控联系在一起，并参与了许多细胞过程。本文综述了KCR的调控机制及其在DDR中的作用，包括参与双链断裂(DSB)诱导的转录抑制、DSB修复和DNA复制应激反应。
The DNA damage response (DDR) system plays an important role in maintaining genome stability and preventing related diseases. The DDR network comprises many proteins and posttranslational modifications (PTMs) to proteins, which work in a coordinated manner to counteract various genotoxic stresses. Lysine crotonylation (Kcr) is a newly identified PTM occurring in both core histone and non-histone proteins in various organisms. This novel PTM is classified as a reversible acylation modification, which is regulated by a variety of acylases and deacylases and the intracellular crotonyl-CoA substrate concentration. Recent studies suggest that Kcr links cellular metabolism with gene regulation and is involved in numerous cellular processes. In this review, we summarize the regulatory mechanisms of Kcr and its functions in DDR, including its involvement in double-strand break (DSB)-induced transcriptional repression, DSB repair, and the DNA replication stress response.
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影响因子：
16
作者：
Elia AE;Boardman AP;Wang DC;Huttlin EL;Everley RA;Dephoure N;Zhou C;Koren I;Gygi SP;Elledge SJ
通讯作者：
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影响因子：
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Elledge SJ