Association between clinical outcome and microbiological findings in peritonsillar abscess - an observational study
Association between clinical outcome and microbiological findings in peritonsillar abscess - an observational study
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扁桃体周围脓肿临床结果与微生物学发现之间的关联——一项观察性研究
DOI：
10.1007/s10096-025-05156-y
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发表时间：
2025-05-14
影响因子：
3.000
通讯作者：
Marie Gisselsson-Solén
中科院分区：
文献类型：
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作者：
Elin Lindberg;Ann Hermansson;David Nygren;Marie Gisselsson-Solén
以前对扁桃体周围脓肿的致病病原体的研究已经产生了不同的结果。然而，A群链球菌（GAS）和坏死梭杆菌(Fusobacterium necrophorum) </i>已被频繁发现。本研究的目的是调查在ß-溶血性链球菌和<i - >F检测的患者腹膜周围脓肿中的病原体。Necrophorum </i>，并研究病原体与临床结果之间的关系。这项回顾性观察性研究纳入了2016年至2020年间瑞典sk<s:1> ne地区诊断为腹膜周围脓肿的所有患者（人口1.4 × 04万），并对这些患者进行了ß-溶血性链球菌（培养）和<i - >F的检测。necrophorum < / i > (PCR)。排除标准包括既往（30天）咽扁桃体炎脓性并发症或抗生素治疗。进行指标访视后6个月前30天的图表回顾。采用逻辑回归来评估病原体与并发症之间的关系，并将微生物学阴性结果作为参考类别。并发症定义为30天（早期）和1-6个月（晚期）复发性咽扁桃体炎/囊周脓肿、其他咽脓肿或脓毒性并发症的复合结局（0/1）。在637例患者中，< 1 bb0 F。210例（33%）、159例（28%）和40例（6%）患者被鉴定为坏死性食管</i>。<我> F。Necrophorum </i>最常见于青少年和青壮年。<我> F。坏死网膜</i>与早期（OR 3.8 (2.0-7.1 95%CI)）和晚期并发症(OR 2.5 （1.3-4.9 95%CI）的发展有关。坏死性坏死菌</i>是腹膜周围脓肿中最常见的病原体。它也是唯一与并发症相关的病原体。
Previous studies on causative pathogens in peritonsillar abscesses have yielded varying results. However, Group A streptococci (GAS) and <i>Fusobacterium necrophorum</i> have been identified frequently. The aim of this study was to investigate pathogens in peritonsillar abscesses in patients tested for both ß-hemolytic streptococci and <i>F. necrophorum</i> , and to investigate associations between pathogens and clinical outcome.This retrospective observational study included all patients in the Skåne Region, Sweden (population 1.4xa0million) with a diagnosis of peritonsillar abscess between 2016 and 20, and in whom tests were performed for both ß-hemolytic streptococci (culture) and <i>F. necrophorum</i> (PCR). Exclusion criteria included previous (30 days) purulent complication to pharyngotonsillitis or antibiotic therapy. Chart review from 30 days prior to 6 months after the index visit was performed. Logistic regression was performed to evaluate the association between pathogens and complications, with negative microbiological findings set as reference category. Complications were defined as a composite outcome (0/1) of recurrent pharyngotonsillitis/peritonsillar abscess, other pharyngeal abscess or septic complications within 30 days (early), and 1–6 months (late).In a total of 637 patients, <i>F. necrophorum</i> was identified in 210 (33%), GAS in 159 (28%) and GCS/GGS in 40 (6%) patients. <i>F. necrophorum</i> was most common in adolescents and young adults. Only <i>F. necrophorum</i> was associated with the development of either of early (OR 3.8 (2.0-7.1 95%CI)) and late complications (OR 2.5 (95%CI 1.3–4.9).<i>F. necrophorum</i> was the most commonly identified pathogen in peritonsillar abscesses. It was also the only pathogen associated with the development of complications.