Antibacterial efficacy of chlorhexidine gluconate intracanal medication in vivo
Antibacterial efficacy of chlorhexidine gluconate intracanal medication in vivo
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DOI：
10.1016/j.joen.2005.12.017
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发表时间：
2007-07-01
影响因子：
4.2
通讯作者：
Friedman, Shimon
中科院分区：
文献类型：
--
作者：
Paquette, Lisane;Legner, Milos;Friedman, Shimon
评价2%洗必泰液根管治疗根尖周炎的抗菌效果。第一次治疗时对22颗牙齿的根管进行了器械治疗，并使用CHX进行药物治疗，并在7至15天后重新进入。在第一次和第二次治疗时，在（1 A，2A）和（1 B，2 B）根管器械之前和之后抽吸细菌学样本。通过培养（CFU）和使用活体染料的显微镜检查获得活菌计数。显微镜计数高于CFU计数。在1个A样本（平均2 × 10（5）μ L-1根管体积）中一致的高CFU计数在1个B样本中显著降低（p < 0.0001），在2A样本中显著升高（p < 0.04），在2B样本中降低至1个B样本的水平。阴性培养物的比例遵循CFU计数模式。CHX的根管内用药并没有降低细菌浓度。细菌计数表示每微升根管体积增加了信息以外的计数每颗牙齿表示在以前的研究。
The antibacterial efficacy of intracanal medication with 2% chlorhexicline liquid (CHX) was assessed in teeth with apical periodontitis. Canals in 22 teeth were instrumented at the first session, medicated with CHX, and reaccessed after 7 to 15 days. Bacteriological samples were aspirated at the first and second sessions, before (1 A, 2A) and after (1 B, 2B) canal instrumentation. Viable bacterial counts were obtained by culture (CFU) and microscopy using vital dyes. Microscopic counts were higher than CFU counts. Consistently high CFU counts in 1 A samples (mean, 2 X 10(5) mu L-1 canal volume) decreased significantly (p < 0.0001) in 1 B samples, increased significantly (p < 0.04) in 2A samples, and decreased in 2B samples to the level of 1B samples. Proportions of negative cultures followed the pattern of CFU counts. Intracanal medication with CHX did not reduce the bacterial concentration. Bacterial counts expressed per microliter canal volume added information beyond the counts per tooth as expressed in previous studies.