Sepsis 2018: Definitions and Guideline Changes
Sepsis 2018: Definitions and Guideline Changes
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DOI：
10.1089/sur.2017.278
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发表时间：
2018-02-01
影响因子：
2
通讯作者：
Napolitano, Lena M.
中科院分区：
文献类型：
--
作者：
Napolitano, Lena M.
背景：脓毒症是一个全球性的医疗保健问题，并且仍然是感染导致死亡的主要原因。需要早期识别和诊断脓毒症以防止转变为脓毒性休克，这与40%或更高的死亡率相关。讨论内容：已制定脓毒症和脓毒性休克的新定义（脓毒症和脓毒性休克的第三次国际共识定义[Sepsis-3]）。已提出一种新的脓毒症筛查工具（快速序贯器官衰竭评估[qSOFA]），用于预测临床疑似脓毒症的重症监护室（ICU）外患者预后不良的可能性。败血症生存运动指南最近进行了更新，包括更多的基于证据的败血症治疗建议，以减少败血症相关的死亡率。本综述讨论了新的脓毒症-3定义和指南。
Background: Sepsis is a global healthcare issue and continues to be the leading cause of death from infection. Early recognition and diagnosis of sepsis is required to prevent the transition into septic shock, which is associated with a mortality rate of 40% or more. Discussion: New definitions for sepsis and septic shock (Third International Consensus Definitions for Sepsis and Septic Shock [Sepsis-3]) have been developed. A new screening tool for sepsis (quick Sequential Organ Failure Assessment [qSOFA]) has been proposed to predict the likelihood of poor outcome in out-of-intensive care unit (ICU) patients with clinical suspicion of sepsis. The Surviving Sepsis Campaign Guidelines were recently updated and include greater evidence-based recommendations for treatment of sepsis in attempts to reduce sepsis-associated mortality. This review discusses the new Sepsis-3 definitions and guidelines.