Microwave-accelerated Claisen rearrangement in bicyclic imidazolium [b-3C-im][NTf2] ionic liquid
Microwave-accelerated Claisen rearrangement in bicyclic imidazolium [b-3C-im][NTf2] ionic liquid
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DOI：
10.1016/j.tet.2007.08.060
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发表时间：
2007-11-05
期刊：
影响因子：
2.1
通讯作者：
Chu, Yen-Ho
中科院分区：
文献类型：
--
作者：
Lin, Yung-Lun;Cheng, Jen-Yen;Chu, Yen-Ho
在微波条件下，以本实验室最近开发的一种化学稳定的离子液体[B-3C-im][NTf 2]为溶剂，成功地应用于高温下Claisen重排反应的加速。在刘易斯酸MgCl 2存在下，这些热重排可以在相似的反应时间内实现，但在较低的温度下。对于在这项工作中研究的微波反应，在不牺牲分离产率的情况下，反应时间从数小时（通过常规加热）显著减少到
With microwaves, a chemically stable ionic liquid [b-3C-im][NTf2] recently developed in our laboratory was used as solvent and successfully applied to accelerate Claisen rearrangement reactions at high temperatures. In the presence of Lewis acid MgCl2, these thermal rearrangements could be achieved in similar reaction times but at lower temperature. For the microwaved reactions studied in this work, without scarifying isolated yields, the reaction times were significantly reduced from hours (by conventional heating) to