GENOMIC INTEGRATION OF BOVINE LEUKEMIA PROVIRUS - COMPARISON OF PERSISTENT LYMPHOCYTOSIS WITH LYMPH-NODE TUMOR FORM OF ENZOOTIC BOVINE LEUKOSIS
GENOMIC INTEGRATION OF BOVINE LEUKEMIA PROVIRUS - COMPARISON OF PERSISTENT LYMPHOCYTOSIS WITH LYMPH-NODE TUMOR FORM OF ENZOOTIC BOVINE LEUKOSIS
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DOI：
10.1073/pnas.77.5.2577
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发表时间：
1980-01-01
期刊：
影响因子：
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通讯作者：
CHANTRENNE, H
中科院分区：
文献类型：
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作者：
KETTMANN, R;CLEUTER, Y;CHANTRENNE, H
在受地方性牛白血病的持续性淋巴细胞增多症或淋巴结肿瘤形式影响的牛中，研究了牛白血病前病毒 DNA 在受感染的[牛]细胞基因组中的整合。在持续性淋巴细胞增多症中，前病毒 DNA 整合在 1/4-1/3 循环白细胞的大量基因组位点上。相反，在淋巴结肿瘤形式中，前病毒DNA整合在大部分循环白细胞和淋巴结肿瘤细胞的基因组中的1个或很少的位点上。
Integration of bovine leukemia proviral DNA in the genome of infected [bovine] cells was investigated in cattle affected by either the persistent lymphocytosis or the lymph node tumor form of enzootic bovine leukosis. In persistent lymphocytosis, proviral DNA was integrated at a large number of genomic sites in 1/4-1/3 of circulating leukocytes. In the lymph node tumor form, in contrast, proviral DNA was integrated at 1 or very few sites in the genomes of a larger fraction of both circulating leukocytes and lymph node tumor cells.