Effects of aldehyde dehydrogenase genotypes on carotid atherosclerosis
Effects of aldehyde dehydrogenase genotypes on carotid atherosclerosis
复制标题
DOI：
10.1016/s0301-5629(03)01015-9
复制
发表时间：
2003-10-01
影响因子：
2.9
通讯作者：
Hori, M
中科院分区：
文献类型：
--
作者：
Narita, M;Kitagawa, K;Hori, M
与白种人相比，动脉粥样硬化性疾病被认为在亚洲人中较少见。与高加索人不同，近一半的亚洲人缺乏低K-m醛脱氢酶（ALDH2），这是酒精代谢的关键酶，可能会改变动脉粥样硬化的患病率。本研究检测了304名日本患者的ALDH2基因型（“典型人”、“异基因”或“非典型人”）与颈动脉粥样硬化之间的关系。b超评价斑块评分（PS）作为颈动脉粥样硬化的指标。经年龄和性别调整后的PS在“非典型人”基因型患者中较低（2.7 +/- 1.2[平均标准误差]，n = 21） （p < 0.05），在“异性”基因型患者中较低（4.5±0.5,n = 116） （p = 0.07），在“典型人”基因型患者中较低（5.7±0.4,n = 167）。当我们控制传统心血管危险因素和酒精摄入量时，发现“非典型人”基因型与较低的PS相关（P = -0.13, P < 0.05）。基于这些发现，ALDH2基因型似乎与颈动脉粥样硬化的严重程度有关，可能改变亚洲人动脉粥样硬化的患病率。（E-mail: kitagawa@medone.med.osaka-u.ac.jp） (C) 2003年世界超声医学生物学联合会。
Atherosclerotic diseases are thought to be less frequent in Asians compared with Caucasians. Unlike Caucasians, nearly half of Asians have a functional deficiency in the low K-m aldehyde dehydrogenase (ALDH2), a key enzyme in alcohol metabolism, which potentially modifies the prevalence of atherosclerosis. This study examined the associations between ALDH2 genotypes ("typical homo," "hetero" or "atypical homo") and carotid atherosclerosis in 304 Japanese patients. As a measure of carotid atherosclerosis, plaque score (PS) was evaluated by B-mode ultrasonography. Age- and sex-adjusted PS was lower in "atypical homo" genotype patients (2.7 +/- 1.2 [mean standard error], n = 21) (p < 0.05) and tended to be lower in "hetero" patients (4.5 ± 0.5, n = 116) (p = 0.07) compared with "typical homo" patients (5.7 ± 0.4, n = 167). When we controlled for traditional cardiovascular risk factors and alcohol intake, the "atypical homo" genotype was found to be associated with lower PS (P = -0.13, p < 0.05). Based on these findings, the ALDH2 genotypes seem to be associated with the severity of carotid atherosclerosis, potentially modifying the prevalence of atherosclerosis in Asians. (E-mail: kitagawa@medone.med.osaka-u.ac.jp) (C) 2003 World Federation for Ultrasound in Medicine Biology.