Effects of iron deficiency on endurance and muscle enzyme activity in man.
Effects of iron deficiency on endurance and muscle enzyme activity in man.
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缺铁对人类耐力和肌肉酶活性的影响。
DOI：
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发表时间：
1986
影响因子：
4.1
通讯作者：
B. Ekblom
中科院分区：
文献类型：
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作者：
F. Celsing;E. Blomstrand;B. Werner;P. Pihlstedt;B. Ekblom
本研究的目的是评价缺铁对酶活性和耐力的影响。9名健康男性受试者通过反复静脉注射诱发铁缺乏症。在9wk(范围，8-11wk)后，当受试者按照实验室参数定义为缺铁时，重新输血以重新建立控制的血红蛋白浓度。在这种状态下，可以评估从贫血中分离出来的缺铁的影响。在肌肉活组织检查的样本中，分析了对照(C)、贫血(A)状态和回输(R)后的糖酵解、氧化和铁依赖酶。所研究的任何一种酶的最大活性都没有显著变化。毛细血管/纤维比值在C(1.92)和R(1.94)之间保持不变。跑台疲劳时间分别为49分钟、11次S、26分钟、33次S和52分钟，S 3次。VO2max为4.55 1×min-1，A为3.74 1×min-1，R为4.45 1×min-1。严重耗尽或缺乏组织铁储备的4周时间并不影响人体骨骼肌中各种酶的最大活性。
The purpose of the present study was to evaluate the effects of iron deficiency on enzyme activities and endurance. Iron deficiency was induced in 9 healthy male subjects by repeated venesections. After a period of 9 wk (range, 8-11 wk) when the subjects had become iron deficient as defined by laboratory parameters, blood was retransfused to reestablish the control hemoglobin concentration. In this state it was possible to evaluate the effect of iron deficiency isolated from anemia. In samples secured by muscle biopsies, glycolytic, oxidative, and iron depending enzymes were analyzed in the control (C) and anemic (A) states and after retransfusion (R). There were no significant changes in the maximal activities of any of the enzymes studied. The capillary/fiber ratio remained unchanged between C (1.92) and R (1.94). Times to exhaustion on treadmill tests were 49 min, 11 s in C, 26 min, 33 s in A, and 52 min, 3 s in R. Vo2max was 4.55 1 X min-1 in C, 3.74 1 X min-1 in A, and 4.45 1 X min-1 in R. An artificially induced iron deficiency defined by conventional laboratory parameters did not affect endurance when transfusion of red blood cells was performed in order to exclude the influence of a low hemoglobin concentration. A 4-wk period of severely depleted or absent tissue iron stores did not affect the maximal activities of various enzymes in human skeletal muscle.