Eccentric contractions induce rapid isometric torque drop in dystrophin-deficient dogs.
Eccentric contractions induce rapid isometric torque drop in dystrophin-deficient dogs.
复制标题
偏心收缩会导致肌营养不良蛋白缺陷狗的等长扭矩快速下降。
DOI：
10.1002/mus.21699
复制
发表时间：
2010
期刊：
影响因子：
3.4
通讯作者：
Childers,MartinK
中科院分区：
文献类型：
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作者：
Tegeler,ChristopherJ;Grange,RobertW;Bogan,DanielJ;Markert,ChadD;Case,Doug;Kornegay,JoeN;Childers,MartinK
我们检验了离心收缩（ECC）在肌营养不良蛋白缺陷型金毛猎犬肌营养不良症（GRMD）肌肉中快速诱导大于正常等长扭矩下降的假设。通过强制拉伸激活的肌肉来施加ECC。结果表明，GRMD组的等长扭矩下降大于对照组（P< 0.0001）。我们的研究结果支持了ECC在GRMD肌肉中诱导大于正常等长扭矩下降的假设。ECC诱导的等长扭矩损失的幅度可能是GRMD模型中的理想临床终点。肌肉神经，2010年
We tested the hypothesis that eccentric contractions (ECCs) rapidly induce greater‐than‐normal isometric torque drop in dystrophin‐deficient golden retriever muscular dystrophy (GRMD) muscles. ECCs were imposed by forcibly stretching activated muscles. The results indicate that isometric torque drop was greater in GRMD versus controls (P< 0.0001). Our findings support the hypothesis that ECCs induce greater‐than‐normal isometric torque drop in GRMD muscles. The magnitude of ECC‐induced isometric torque loss may be an ideal clinical endpoint in the GRMD model. Muscle Nerve, 2010