DEPRESSION OF GROWTH IN HYPERACTIVE CHILDREN ON STIMULANT DRUGS
DEPRESSION OF GROWTH IN HYPERACTIVE CHILDREN ON STIMULANT DRUGS
复制标题
DOI：
10.1056/nejm197208032870503
复制
发表时间：
1972-01-01
影响因子：
158.5
通讯作者：
ALLEN, R
中科院分区：
文献类型：
--
作者：
SAFER, D;BARR, E;ALLEN, R
在29名多动症儿童中，苯丙胺（每天10或15毫克）和哌醋甲酯（每天30或40毫克）引起体重增加的抑制。9名儿童在两年的药物治疗中平均每年体重增加1.8公斤，而预期体重增加3.1公斤。身高增长的抑制程度各不相同;然而，生长受到抑制的儿童身高增长也受到相应的抑制。13名服用刺激性药物9个月或更长时间的儿童在突然停药时体重反弹。右旋苯丙胺对体重增加的抑制与剂量无关，且显著大于哌甲酯。每日剂量为20 mg的哌甲酯并不能抑制体重增加。
In 29 hyperactive children, dextroamphetamine (10 or 15 mg per day) and methylphenidate (30 or 40 mg per day) caused suppression of weight gain. Mean yearly weight gain of nine children on medication for two years was 1.8 kg as compared to the expected gain of 3.1 kg. Depression of growth in height varied in degree; however, children whose growth was depressed also had proportional depression of growth in height.Thirteen children who took stimulant drugs for nine or more months showed a rebound weight gain when medication was abruptly stopped. Dextroamphetamine inhibition of weight gain was not related to dose and was significantly greater than that observed with methylphenidate. Daily doses of 20 mg of methylphenidate did not inhibit weight gain.