Effects of climatic factors on plasma lipid levels: A 5-year longitudinal study in a large Chinese population
Effects of climatic factors on plasma lipid levels: A 5-year longitudinal study in a large Chinese population
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气候因素对血脂水平的影响：一项针对中国大型人群的 5 年纵向研究
DOI：
10.1016/j.jacl.2016.06.009
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发表时间：
2016-10-01
影响因子：
4.4
通讯作者：
Zhang, Qunye
中科院分区：
文献类型：
--
作者：
Zhou, Xiaoming;Lin, Haiyan;Zhang, Qunye
背景：血脂水平季节性变化的规律和机制仍存在争议，其可能与心血管疾病发病和死亡的年节律性有关。目的：研究气候因素对血脂水平的影响，初步揭示血脂水平年节律性的机制。 利用中国济南市连续5年（47,270名受试者）的健康检查数据进行纵向研究。济南气候为典型的温带大陆性季风气候，冬夏温差巨大（>30℃）。结果：在考虑和调整年龄、性别、饮食、运动、血压、体重、体重变化、体重指数、血糖、谷丙转氨酶、肌酐等经典血脂相关危险因素后，只有气温仍能显着影响血脂相关风险。 血脂水平是主要气候因素（湿度、降水等）中的一个。对于男性来说，气温每升高10℃，总胆固醇、高密度脂蛋白胆固醇和低密度脂蛋白胆固醇分别显着降低0.35、0.18和0.06 mmol/L，而甘油三酯则显着升高0.12 mmol/L。对于女性来说，气温每升高10℃，总胆固醇和高密度脂蛋白胆固醇分别显着降低0.73和0.32 mmol/L，低密度脂蛋白胆固醇显着升高0.26 mmol/L，而甘油三酯受气温影响不显着。 结论：气温是除经典因素外血脂水平的独立危险因素。 脂质相关的危险因素。年气温波动可能是脂质季节变化的重要机制。 (C) 2016 年国家脂质协会。版权所有。
BACKGROUND: The rules and mechanisms of seasonal changes in plasma lipid levels, which may be related to annual rhythmicity of incidence and mortality of cardiovascular diseases, are still controversial.OBJECTIVE: The objectives of this study were to study the effects of climatic factors on plasma lipid levels and to preliminarily reveal mechanisms of annual rhythmicity of plasma lipid levels.METHODS: A longitudinal study was performed using health examination data of 5 consecutive years (47,270 subjects) in Jinan, China. The climate in Jinan is typical temperate continental monsoon climate with huge temperature difference between winter and summer (>30 degrees C).RESULTS: After considering and adjusting those classical lipid-associated risk factors, such as age, gender, diet, exercise, blood pressure, body weight, change of body weight, body mass index, glycemia, alanine aminotransferase, and creatinine, only air temperature could still significantly affect plasma lipid levels among the main climatic factors (humidity, precipitation, and so forth). For men, total cholesterol, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol was decreased significantly 0.35, 0.18, and 0.06 mmol/L, respectively, whereas triglyceride was increased significantly 0.12 mmol/L for every 10 degrees C increase in air temperature. For women, total cholesterol and high-density lipoprotein cholesterol were decreased notably 0.73 and 0.32 mmol/L, and low-density lipoprotein cholesterol was increased significantly 0.26 mmol/L for every 10 degrees C increase in air temperature, whereas triglyceride was not significantly affected by air temperature.CONCLUSION: Air temperature is an independent risk factor for plasma lipid levels besides those classical lipid-associated risk factors. The annual air temperature fluctuations might be an important mechanism of the seasonal changes of lipids. (C) 2016 National Lipid Association. All rights reserved.