Evidence that glucocorticosteroids block expression of the human interleukin-6 gene by accessory cells.
Evidence that glucocorticosteroids block expression of the human interleukin-6 gene by accessory cells.
复制标题
糖皮质激素阻断辅助细胞表达人白细胞介素 6 基因的证据。
DOI：
10.1097/00007890-199001000-00040
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发表时间：
1990
期刊：
影响因子：
6.2
通讯作者：
Strom,TB
中科院分区：
文献类型：
--
作者：
Zanker,B;Walz,G;Wieder,KJ;Strom,TB
糖皮质激素作为免疫抑制剂和免疫抑制剂的作用方式尚未完全了解。糖皮质激素通过干扰IL-1 β基因的转录来阻断白细胞介素1的合成。糖皮质激素也可诱导IL-1 mRNA的快速降解。在抗原存在下，IL-1是一种有效的辅助细胞衍生的生长和分化辅助因子，用于刺激静息T淋巴细胞。最近定义的白细胞介素6蛋白在促进T细胞生长和分化方面甚至比IL-1更强大，并且与IL-1协同作用。与IL-1一样，IL-6由辅助细胞产生并表现出多效性功能。本文描述了糖皮质激素对IL-6合成的影响。我们提供的证据表明，糖皮质激素阻止人外周血单核细胞IL-6基因转录。
The mode of action of glucocorticosteroids as immunosuppressive and antiinflammatory agents is not fully understood. Glucocorticosteroids block synthesis of interleukin 1 by interfering with the transcription of the IL-1 beta gene. Glucocorticosteroids may also induce rapid degradation of IL-1 mRNA. In the presence of antigen, IL-1 is a potent accessory-cell-derived growth and differentiation co-factor for stimulating resting T lymphocytes. The recently defined interleukin 6 protein is even more powerful than IL-1 in promoting T cell growth and differentiation and acts synergistically with IL-1. Like IL-1, IL-6 is produced by accessory cells and exhibits pleiotropic functions. We herein describe the effects of glucocorticosteroids on IL-6 synthesis. We provide evidence that glucocorticosteroids prevent IL-6 gene transcription in human peripheral blood mononu-clear cells.