Acute changes in endocrine and fluid balance markers during high-intensity, steady-state, and prolonged endurance running: unexpected increases in oxytocin and brain natriuretic peptide during exercise
Acute changes in endocrine and fluid balance markers during high-intensity, steady-state, and prolonged endurance running: unexpected increases in oxytocin and brain natriuretic peptide during exercise
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DOI：
10.1530/eje-08-0064
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发表时间：
2008-12-01
影响因子：
5.8
通讯作者：
Verbalis, Joseph G.
中科院分区：
文献类型：
--
作者：
Hew-Butler, Tamara;Noakes, Timothy D.;Verbalis, Joseph G.
在身体压力增加的时期维持体液平衡可能是最好的：使用运动作为模型在人类中进行评估。虽然精氨酸加压素（AVP）、醛固酮和心房利钠肽（ANP）是静息状态下调节体液平衡的主要激素，但其他相关内分泌因子如催产素（OT）和脑利钠肽（BNP）在运动中的潜在作用尚未得到很好的描述。七名经过耐力训练的跑步者完成了三个独立的跑步试验：最大强度的疲劳测试（高强度），60分钟的跑步机跑步（稳定状态）。和56公里的超级马拉松（长时间耐力运动）。仅在超级马拉松后发现[AVP]（p）的统计学显著性跑步前后增加（1.9 vs 6.7 pg/ml; P < 0.05），[OT]（p）（1.5 vs 3.5 pg/ml; P < 0.05），[NT-proBNP]（p）（23.6 vs.117.9 pg/ml; P < 0.01），[白细胞介素6]（p）（4.0 vs 59.6 pg/ml; P < 0.05），[皮质醇]（p）（14.6 vs 32.6 μ g/ml; P < 0.01），[皮质酮]（p）（652.8 vs 3491.4 ng/ml; P < 0.05）和[11-脱氧皮质醇]（p）（0.1 vs 0.5 μ g/ml; P < 0.05），而在高强度刺激后记录到[醛固酮]（p）的显著运行后增加。（4.9 vs 12.5 ng/ml; P < 0.05）、稳态（6.1 vs 16.9 ng/ml; P < 0.05）和长时间耐力跑（2.6 vs 19.7 ng/ml; P < 0.05）。类似地，液体平衡参数的变化在超马拉松与高强度和稳态跑步之间在血浆体积收缩（收缩百分比减少）、体重减轻（体重减轻百分比增加）方面存在显著差异。血浆[Na（+）] δ（较基线降低）和尿液渗透压摩尔浓度δ（较基线升高）。[OT]（p）和[AVP]（p）之间的假设驱动关系（r = 0.69; P < 0.01）以及[NT-proBNP]（p）Delta与血浆[Na（+）] Delta之间（r= -0.79; P < 0.001）-结合长时间耐力运动后赛前至赛后的显著和意想不到的增加-允许可能的推测，OT和BNP可能在极端的身体压力条件下帮助它们更好地已知的伴随激素（AVP和ANP）调节或流体平衡。
Maintenance of fluid homeostasis during periods of heightened physical stress can be best: evaluated in humans using exercise as a model. Although it is well established that arginine vasopressin (AVP), aldosterone and atrial natriuretic peptide (ANP) are the principle hormones regulating fluid balance at rest, the potential contributions of other related endocrine factors, such as oxytocin (OT) and brain natriuretic peptide (BNP), have not been well described during exercise. Seven endurance-trained runners completed three separate running trials: a maximal test to exhaustion (high intensity), a 60-min treadmill run (steady state). and a 56 km ultramarathon (prolonged endurance exercise). Statistically significant pre- to post-run increases were found only following the ultramarathon in [AVP](p) (1.9 vs 6.7 pg/ml; P < 0.05), [OT](p) (1.5 vs 3.5 pg/ml; P < 0.05), [NT-proBNP](p) (23.6 vs.117.9 pg/ml; P < 0.01), [interleukin 6](p) (4.0 vs 59.6 pg/ml; P < 0.05), [cortisol](p) (14.6 vs 32.6 mu g/ml; P < 0.01), [corticosterone](p) (652.8 vs 3491.4 ng/ml; P < 0.05) and [11-deoxycortisol](p) (0.1 vs 0.5 mu g/ml; P < 0.05) while a significant post-run increase in [aldosterone](p) was documented after high-intensity (4.9 vs 12.5 ng/ml; P < 0.05), steady-state (6.1 vs 16.9 ng/ml; P < 0.05) and prolonged endurance running (2.6 vs 19.7 ng/ml; P < 0.05). Similarly, changes in fluid balance parameters were significantly different between the ultramarathon versus high-intensity and steady-state running with regard to plasma volume contraction (less % contraction), body weight loss (increased % weight loss). plasma [Na(+)] Delta (decreased from baseline), and urine osmolality Delta (increase from baseline). Hypothetically driven relationships between [OT](p) and [AVP](p) (r = 0.69; P < 0.01) and between [NT-proBNP](p) Delta and plasma [Na(+)] Delta (r= -0.79; P < 0.001) - combined with the significant and unexpected pre- to post-race increases after prolonged endurance exercise - allows for possible speculation that OT and BNP may assist their better known companion hormones (AVP and ANP) in the regulation or fluid balance during conditions of extreme physical stress.