A case-control study of respiratory disease in Thoroughbred racehorses in Sydney, Australia
A case-control study of respiratory disease in Thoroughbred racehorses in Sydney, Australia
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DOI：
10.2746/042516401776249796
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发表时间：
2001-05-01
影响因子：
2.2
通讯作者：
Hodgson, JL
中科院分区：
文献类型：
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作者：
Christley, RM;Hodgson, DR;Hodgson, JL
为了调查传染源在纯种赛马下呼吸道疾病病因学中的作用，进行了一项匹配的病例对照研究。通过咳嗽的情况来识别病例，并与同一训练机构内样本采集时间和地点相匹配的对照人群进行比较。从 100 例病例和 148 名对照中收集了气管冲洗样本。病例马比对照更有可能具有气道炎症的内窥镜和细胞学证据。通常涉及的呼吸道病毒感染的血清学证据与咳嗽之间没有显着关联。同样，支原体很少被分离出来，并且与疾病无关。相比之下，气管冲洗液中分离出的菌落形成单位总数超过 10(3) 个单位/ml 与咳嗽之间存在很强的相关性。与疾病相关的个别细菌种类包括兽疫链球菌、肺炎链球菌、猪链球菌、血链球菌、巴氏杆菌属和支气管败血博德特氏菌。这项研究提供了细菌感染在赛马下呼吸道炎症病因学中的作用的证据。然而，在58%的病例中，很少或没有分离到细菌，因此，在鉴定疾病时，大多数咳嗽马匹没有病毒、细菌或支原体感染的证据。在这些马身上观察到的症状的病因学需要进一步调查。
In order to investigate the role of infectious agents in the aetiology of lower respiratory tract disease in Thoroughbred racehorses, a matched case-control study was conducted. Cases were identified by the presence of coughing, and were compared to a control population matched on time of sample collection and location within the same training establishment Tracheal wash samples were collected from 100 cases and 148 controls, Case horses were more likely than controls to have endoscopic and cytological evidence of airway inflammation. There was no significant association between serological evidence of infection by commonly implicated respiratory viruses and coughing. Similarly, mycoplasma were rarely isolated and were not associated with disease. In contrast, there was a strong association between isolation of greater than a total of 10(3) colony-forming units/ml of tracheal wash and coughing. Individual bacterial species associated with disease included Streptococcus zooepidemicus, Streptococcus pneumoniae, Streptococcus suis, Streptococcus sanguis, Pasteurella spp and Bordetella bronchiseptica. This study provides evidence of the role of bacterial infection in the aetiology of lower respiratory tract inflammation in racehorses. However in 58% of cases, few or no bacteria were isolated, Hence, at the time of identification of disease, there was no evidence of viral, bacterial or mycoplasmal infection in the majority of coughing horses. The aetiology of the signs observed in these horses requires further investigation.