Age and gender dependency of baroreflex sensitivity in healthy subjects
Age and gender dependency of baroreflex sensitivity in healthy subjects
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DOI：
10.1152/jappl.1998.84.2.576
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发表时间：
1998-02-01
影响因子：
3.3
通讯作者：
Länsimies, E
中科院分区：
文献类型：
--
作者：
Laitinen, T;Hartikainen, J;Länsimies, E
我们评估了健康受试者压力反射敏感性（BRS）的相关性。该研究由 117 名年龄 23-77 岁的健康、体重正常、不吸烟的男性和女性受试者组成。通过使用去氧肾上腺素推注技术来测量心率的压力反射控制。进行了心率变异性的频域和时域分析以及运动测试。测量血浆去甲肾上腺素、肾上腺素、胰岛素和精氨酸加压素浓度以及血浆肾素活性。在单变量分析中，BRS 与年龄（r = -0.65，P < 0.001）、舒张压（r = -0.47，P-e 0.001）、运动能力（r = 0.60，P < 0.001）和心率变异性高频成分（r = 0.64，P < 0.001）相关。 BRS 与血浆去甲肾上腺素浓度（r = -0.22，P < 0.05）和血浆肾素活性（r = 0.32，P < 0.001）之间也存在显着相关性。根据多变量分析，年龄和性别是 BRS 最重要的生理相关因素。它们占个体间 BRS 变异的 52%。此外，舒张压和心率变异性的高频成分与 BRS 具有显着的独立相关性。男性的 BRS 显着高于女性（分别为 15.0 +/- 1.2 vs. 10.2 +/- 1.1 ms/mmHg；P < 0.01）。 24% 的 40 岁以上女性和 18% 60 岁以上男性有明显的坐姿抑郁症状（
We evaluated the correlates of baroreflex sensitivity (BRS) in healthy subjects. The study consisted of 117 healthy, normal-weight, nonsmoking male and female subjects aged 23-77 yr. Baroreflex control of heart rate was measured by using the phenylephrine bolus-injection technique. Frequency- and time-domain analysis of heart rate variability and an exercise test were performed. Plasma norepinephrine, epinephrine, insulin, and arginine vasopressin concentrations and plasma renin activity were measured. In the univariate analysis, BRS correlated with age (r = -0.65, P < 0.001), diastolic blood pressure (r = -0.47, P-e 0.001), exercise capacity (r = 0.60, P < 0.001), and the high-frequency component of heart rate variability (r = 0.64, P < 0.001). There was also a significant correlation between BRS and plasma norepinephrine concentration (r = -0.22, P < 0.05) and plasma renin activity (r = 0.32, P < 0.001). According to the multivariate analysts, age and gender were the most important physiological correlates of BRS. They accounted for 52% of interindividual BRS variation. In addition, diastolic blood pressure and high-frequency component of heart rate variability were significant independent correlates of BRS. BRS was significantly higher in men than in women(15.0 +/- 1.2 vs. 10.2 +/- 1.1 ms/mmHg, respectively; P < 0.01). Twenty-four percent of women >40 vr old and 18% of men >60 yr old had markedly depressed sits (