Oxidative stress and nerve damage: role in chemotherapy induced peripheral neuropathy.
Oxidative stress and nerve damage: role in chemotherapy induced peripheral neuropathy.
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DOI：
10.1016/j.redox.2014.01.006
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发表时间：
2014
期刊：
影响因子：
11.4
通讯作者：
Kumar A
中科院分区：
文献类型：
--
作者：
Areti A;Yerra VG;Naidu V;Kumar A
周围神经病变是与癌症化疗相关的严重剂量限制性毒性。化疗诱导的周围神经病变（chemotherapy induced peripheral neuropathy，CIPN）自被发现以来，其病理机制一直不清楚，近年来氧化应激和神经炎症的参与逐渐被认识。尽管抗氧化剂在CIPN治疗中的经验性使用，但氧化应激介导的周围神经病变中的神经元损伤仍然存在争议。目前的审查重点是神经损伤，由于氧化应激和线粒体功能障碍的关键致病机制参与CIPN。氧化应激作为细胞凋亡，神经炎症，代谢紊乱和神经元的生物能量衰竭的中央介质已被强调在这篇综述沿着与饮食抗氧化剂和其他营养品的研究进行了前瞻性对照临床试验，在接受化疗的患者的总结。天然抗氧化剂靶向治疗化疗引起的周围神经病变。氧化应激参与了化疗诱导的周围神经病（CIPN）的病理生理学。线粒体毒性和线粒体功能障碍导致氧化应激放大。针对维持线粒体健康和功能的药理学干预可能对CIPN有益。
Peripheral neuropathy is a severe dose limiting toxicity associated with cancer chemotherapy. Ever since it was identified, the clear pathological mechanisms underlying chemotherapy induced peripheral neuropathy (CIPN) remain sparse and considerable involvement of oxidative stress and neuroinflammation has been realized recently. Despite the empirical use of antioxidants in the therapy of CIPN, the oxidative stress mediated neuronal damage in peripheral neuropathy is still debatable. The current review focuses on nerve damage due to oxidative stress and mitochondrial dysfunction as key pathogenic mechanisms involved in CIPN. Oxidative stress as a central mediator of apoptosis, neuroinflammation, metabolic disturbances and bioenergetic failure in neurons has been highlighted in this review along with a summary of research on dietary antioxidants and other nutraceuticals which have undergone prospective controlled clinical trials in patients undergoing chemotherapy. Targeting chemotherpay induced peripheral neuropathy with natural antioxidants. Oxidative stress contributes to the pathophysiology of chemotherapy induced peripheral neuropathies (CIPN). Mitotoxicity and mitochondrial dysfunction contribute to amplified oxidative stress. Pharmacological interventions targeted at maintenance of mitochondrial health and function may be beneficial against CIPN.
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影响因子：
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