Model of cellular and network mechanisms for odor-evoked temporal patterning in the locust antennal lobe
Model of cellular and network mechanisms for odor-evoked temporal patterning in the locust antennal lobe
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DOI：
10.1016/s0896-6273(01)00286-0
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发表时间：
2001-05-01
期刊：
影响因子：
16.2
通讯作者：
Laurent, G
中科院分区：
文献类型：
--
作者：
Bazhenov, M;Stopfer, M;Laurent, G
蝗虫触角叶(AL)投射神经元(PN)对嗅觉刺激的反应具有去极化和超极化的周期序列，每个周期持续数百毫秒。使用AL网络的计算机模拟来检验局部神经元(LNS)和PNS之间缓慢的抑制性连接是导致时间模式的假设。由构成三叉神经核快速振荡同步的相同GABA能突触激活三叉神经节上的慢抑制受体，足以形成慢反应调制。这种慢刺激和神经元特异性的AL活动模式对快速抑制的阻断具有抵抗力。因此，LNS和PNS之间突触的快速和缓慢抑制机制可以形成动态的PN组件，其元件瞬时同步并集体振荡，不仅在蝗虫AL中观察到，而且在脊椎动物嗅球中也观察到。
Locust antennal lobe (AL) projection neurons (PNs) respond to olfactory stimuli with sequences of depolarizing and hyperpolarizing epochs, each lasting hundreds of milliseconds. A computer simulation of an AL network was used to test the hypothesis that slow inhibitory connections between local neurons (LNs) and PNs are responsible for temporal patterning. Activation of slow inhibitory receptors on PNs by the same GABAergic synapses that underlie fast oscillatory synchronization of PNs was sufficient to shape slow response modulations. This slow stimulus- and neuron-specific patterning of AL activity was resistant to blockade of fast inhibition. Fast and slow inhibitory mechanisms at synapses between LNs and PNs can thus form dynamical PN assemblies whose elements synchronize transiently and oscillate collectively, as observed not only in the locust AL, but also in the vertebrate olfactory bulb.