Volumetric Optoacoustic Temperature Mapping in Photothermal Therapy.
Volumetric Optoacoustic Temperature Mapping in Photothermal Therapy.
复制标题
光热治疗中的体积光声映射。
DOI：
10.1038/s41598-017-09069-5
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发表时间：
2017-08-29
影响因子：
4.6
通讯作者：
Razansky D
中科院分区：
文献类型：
--
作者：
Landa FJO;Deán-Ben XL;Sroka R;Razansky D
Photothermal therapy and ablation are commonplace medical procedures employed for treatment of tumors, vascular and brain abnormalities as well as other disorders that require selective destruction of tissues. Yet, accurate mapping of the dynamic temperature field distribution in the treated region represents an unmet clinical need, strongly affecting the clinical outcome of these interventions. We introduce a fast three-dimensional temperature mapping method based on real-time optoacoustic sensing of the treated region coupled with a thermal-diffusion-based model of heat distribution in tissues. Deviations of the optoacoustic temperature readings provided at 40 ms intervals remained below 10% in tissue-mimicking phantom experiments for temperature elevations above 3 °C, as validated by simultaneous thermocouple measurements. Performance of the new method to dynamically estimate the volumetric temperature distribution was further showcased in post-mortem mouse imaging experiments. The newly discovered capacity to non-invasively measure the temperature map in an entire treated volume with both high spatial and temporal resolutions holds potential for improving safety and efficacy of light-based therapeutic interventions.
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DOI：
10.3109/02656736.2015.1009180
发表时间：
2015-03
期刊：
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
影响因子：
--
作者：
Lewis MA;Staruch RM;Chopra R
通讯作者：
Chopra R
影响因子：
4
作者：
Liu, Liwang;Creten, Sebastiaan;Glorieux, Christ
通讯作者：
Glorieux, Christ
DOI：
10.1016/j.ijheatmasstransfer.2012.02.069
发表时间：
2012-06-01
影响因子：
5.2
作者：
Shih, Tzu-Ching;Horng, Tzyy-Leng;Lin, Win-Li
通讯作者：
Lin, Win-Li
影响因子：
3.9
作者：
Torres-Reveron, Juan;Tomasiewicz, Hilarie C.;Chiang, Veronica L.
通讯作者：
Chiang, Veronica L.
影响因子：
46.2
作者：
Deán-Ben XL;Gottschalk S;Mc Larney B;Shoham S;Razansky D
通讯作者：
Razansky D