Evolution of the H9N2 influenza genotype that facilitated the genesis of the novel H7N9 virus
Evolution of the H9N2 influenza genotype that facilitated the genesis of the novel H7N9 virus
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DOI：
10.1073/pnas.1422456112
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发表时间：
2015-01-13
影响因子：
11.1
通讯作者：
Webster, Robert G.
中科院分区：
文献类型：
--
作者：
Pu, Juan;Wang, Shuoguo;Webster, Robert G.
中国出现人类感染新型 H7N9 流感病毒的情况引起了人们对大流行病的担忧。鸡 H9N2 病毒提供了新型重配体的所有六个内部基因。然而，目前尚不完全清楚这些 H9N2 鸡病毒的流行和进化如何促进新型 H7N9 病毒的发生。在这里，我们表明，在多种 H9N2 基因型共循环超过 10 年的过程中，出现了一种基因型 (G57)，该基因型改变了鸡的抗原性并提高了适应性。它在中国接种疫苗的农场鸡中占主导地位，在H7N9病毒在人类中出现之前的2010-2013年引起了广泛的疫情，并最终将其所有内部基因提供给了新型H7N9病毒。 H9N2 流感病毒在养殖家禽中的流行和变异可以为具有大流行潜力的新型重配病毒的出现提供重要的早期预警。
The emergence of human infection with a novel H7N9 influenza virus in China raises a pandemic concern. Chicken H9N2 viruses provided all six of the novel reassortant's internal genes. However, it is not fully understood how the prevalence and evolution of these H9N2 chicken viruses facilitated the genesis of the novel H7N9 viruses. Here we show that over more than 10 y of cocirculation of multiple H9N2 genotypes, a genotype (G57) emerged that had changed antigenicity and improved adaptability in chickens. It became predominant in vaccinated farm chickens in China, caused widespread outbreaks in 2010-2013 before the H7N9 viruses emerged in humans, and finally provided all of their internal genes to the novel H7N9 viruses. The prevalence and variation of H9N2 influenza virus in farmed poultry could provide an important early warning of the emergence of novel reassortants with pandemic potential.