Optimization of sample transfer in two-dimensional microfluidic separation systems.
Optimization of sample transfer in two-dimensional microfluidic separation systems.
复制标题
二维微流体分离系统中样品传输的优化。
DOI：
10.1039/b801978a
复制
发表时间：
2008
期刊：
影响因子：
6.1
通讯作者：
DeVoe,DonL
中科院分区：
文献类型：
--
作者：
Yang,Shuang;Liu,Jikun;DeVoe,DonL
将第一维微通道与平行的第二维微通道阵列组合在一起的多维微流控分离系统可能遭受维度之间的不均匀样品转移、样品泄漏和第二维阵列内的注入插头拖尾。这些因素会显著降低整体二维分离性能。在本文中，数值模型和分析模型揭示了一种优化的芯片设计，它结合了多维背偏和倾斜的通道几何结构，以确保无泄漏和均匀的维间样品传输，同时还最大限度地减少了注入样品塞的长度。利用包含五个二维通道的多维芯片对优化设计进行了实验验证。
Multidimensional microfluidic separation systems combining a first dimension microchannel with an array of parallel second dimension microchannels can suffer from non-uniform sample transfer between the dimensions, sample leakage, and injection plug tailing within the second dimension array. These factors can significantly reduce overall two-dimensional separation performance. In this paper, numerical and analytical models reveal an optimized chip design which combines multidimensional backbiasing and an angled channel geometry to ensure leakage-free and uniform interdimensional sample transfer, while also minimizing injected sample plug lengths. The optimized design is validated experimentally using a multidimensional chip containing five second dimension channels.