Simultaneous early processing of sensory input in human primary (SI) and secondary (SII) somatosensory cortices
Simultaneous early processing of sensory input in human primary (SI) and secondary (SII) somatosensory cortices
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DOI：
10.1152/jn.1999.81.5.2017
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发表时间：
1999-05-01
影响因子：
2.5
通讯作者：
Tesche, CD
中科院分区：
文献类型：
--
作者：
Karhu, J;Tesche, CD
躯体感觉系统的解剖学连接支持广泛分离的皮层区域同时参与感觉输入的早期处理。我们记录了诱发的神经磁反应非侵入性从人类初级（SI）和次级（SII）体感皮层单侧正中神经刺激。在手腕处以2 Hz重复地向正中神经施加简短的电流脉冲，进行800- 1，500次试验。一个单一的脉冲被省略的火车在随机间隔（15%的遗漏）。我们观察到同步的神经元群体活动在对侧SII区刺激后20-30毫秒，在时间上与第一次在SI中产生的反应。对侧和同侧SII区在50-60 ms时均表现出显著的活动，与对侧反应相比，同侧的平均延迟为13 ms。不应期行为的早期SII响应的遗漏不同，在类似于100毫秒，指示不同的神经元组件响应在每个潜伏期。这些结果表明，SII和/或相关的皮质顶叶盖，通常被视为高阶处理领域的体感知觉，共激活SI在间歇性体感输入的早期处理。
The anatomic connectivity of the somatosensory system supports the simultaneous participation of widely separated cortical areas in the early processing of sensory input. We recorded evoked neuromagnetic responses noninvasively from human primary (SI) and secondary (SII) somatosensory cortices to unilateral median nerve stimulation. Brief current pulses were applied repetitively to the median nerve at the wrist at 2 Hz for 800-1,500 trials. A single pulse was omitted from the train at random intervals (15% of omissions). We observed synchronized neuronal population activity in contralateral SII area 20-30 ms after stimulation, coincident in time with the first responses generated in SI. Both contra- and ipsilateral SII areas showed prominent activity at 50-60 ms with an average delay of 13 ms for ipsilateral compared with contralateral responses. The refractory behavior of the early SII responses to the omissions differed from those observed at similar to 100 ms, indicative of distinct neuronal assemblies responding at each latency. These results indicate that SII and/or associated cortices in parietal operculum, often viewed as higher-order processing areas for somatosensory perception, are coactivated with SI during the early processing of intermittent somatosensory input.