Cytoskeletal and adhesion proteins as tumor suppressors
Cytoskeletal and adhesion proteins as tumor suppressors
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DOI：
10.1016/s0955-0674(97)80158-5
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发表时间：
1997-02-01
影响因子：
7.5
通讯作者：
BenZeev, A
中科院分区：
文献类型：
--
作者：
BenZeev, A
在过去的一年中，已经取得了显着的进展，在试图了解潜在的信号传导，诱导细胞-细胞和细胞-细胞外基质粘附，并涉及细胞骨架的分子机制。特别是，细胞-细胞连接的细胞质斑块的分子已被证明与转录因子复合并易位到细胞核中。此外，这种连接斑蛋白已被证明是肿瘤发生的有效抑制剂。
In the past year, significant progress has been made in the attempt to understand the molecular mechanisms underlying signaling that is induced by cell-cell and cell-extracellular-matrix adhesion and that involves the cytoskeleton. In particular, molecules of the cytoplasmic plaques of cell-cell junctions have been shown to complex with transcription factors and to translocate into the nucleus. In addition, such junctional plaque proteins have been shown to act as effective suppressors of tumorigenesis.