Wnt signaling controls the timing of oligodendrocyte development in the spinal cord
Wnt signaling controls the timing of oligodendrocyte development in the spinal cord
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DOI：
10.1016/j.ydbio.2005.03.020
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发表时间：
2005-06-15
影响因子：
2.7
通讯作者：
Ikenaka, K
中科院分区：
文献类型：
--
作者：
Shimizu, T;Kagawa, T;Ikenaka, K
在脊髓发育过程中，少突胶质细胞从腹侧脑室区域的有限区域产生，然后扩散到整个脊髓。这些事件由来自当地组织中心的分级感应和抑制信号控制。Sonic Hedgehog被认为是少突胶质细胞谱系确定的一个重要的腹侧因素，而背侧线索不太清楚。在本研究中，WRIT蛋白被确定为直接抑制少突胶质细胞发育的背部因子。WRIT信号通过典型的β-连环蛋白途径阻止其从祖细胞分化为未成熟状态。加入WRIT拮抗剂rmFz-8/Fc可增加脊髓外植体培养中未成熟少突胶质细胞的数量，表明内源性WRIT信号控制少突胶质细胞的发育。(C)2005 Elsevier Inc.保留所有权利。
During spinal cord development, oligodendrocytes are generated from a restricted region of the ventral ventricular zone and then spread out into the entire spinal cord. These events are controlled by graded inductive and repressive signals derived from a local organizing center. Sonic hedgehog was identified as an essential ventral factor for oligodendrocyte lineage specification, whereas the dorsal cue was less clear. In this study, Writ proteins were identified as the dorsal factors that directly inhibit oligodendrocyte development. Writ signaling through a canonical beta-catenin pathway prevents its differentiation from progenitor to an immature state. Addition of rmFz-8/Fc, a Writ antagonist, increased the number of immature oligodendrocytes in the spinal cord explant culture, demonstrating that endogenous Writ signaling controls oligodendrocyte development. (c) 2005 Elsevier Inc. All rights reserved.