Disturbed sleep: linking allergic rhinitis, mood and suicidal behavior.
Disturbed sleep: linking allergic rhinitis, mood and suicidal behavior.
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DOI：
10.2741/s44
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发表时间：
2010
期刊：
影响因子：
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通讯作者：
Beverly Fang;L. Tonelli;Joseph J. Soriano;T. Postolache,
中科院分区：
文献类型：
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作者：
Beverly Fang;L. Tonelli;Joseph J. Soriano;T. Postolache,
过敏性炎症与情绪障碍、抑郁症加重和自杀行为有关。炎症介质调节睡眠，Th1细胞因子促进NREM睡眠并增加嗜睡，Th2细胞因子（在过敏性炎症期间产生）损害睡眠。由于睡眠障碍是一种与情绪障碍密切相关的可迅速改变的自杀风险因素，我们回顾了导致过敏性鼻炎导致情绪和焦虑障碍以及通过睡眠障碍增加自杀风险的假设的文献。具体来说，过敏性鼻炎可以通过机械（阻塞性）和分子（细胞因子产生）过程损害睡眠。情绪和焦虑障碍和过敏症的高患病率，自杀的发生率，目前可用的治疗方式来治疗睡眠障碍和需要新的治疗目标的情绪和焦虑障碍，证明多层次的努力，探索睡眠障碍的病理生理联系。
Allergic inflammation is associated with mood disorders, exacerbation of depression, and suicidal behavior. Mediators of inflammation modulate sleep , with Th1 cytokines promoting NREM sleep and increasing sleepiness and Th2 cytokines (produced during allergic inflammation) impairing sleep. As sleep impairment is a rapidly modifiable suicide risk factor strongly associated with mood disorders, we review the literature leading to the hypothesis that allergic rhinitis leads to mood and anxiety disorders and an increased risk of suicide via sleep impairment. Specifically, allergic rhinitis can impair sleep through mechanical (obstructive) and molecular (cytokine production) processes. The high prevalence of mood and anxiety disorders and allergy, the nonabating suicide incidence, the currently available treatment modalities to treat sleep impairment and the need for novel therapeutic targets for mood and anxiety disorders, justify multilevel efforts to explore disturbance of sleep as a pathophysiological link.