The Resting State Central Auditory Network: a Potential Marker of HIV-Related Central Nervous System Alterations.
The Resting State Central Auditory Network: a Potential Marker of HIV-Related Central Nervous System Alterations.
复制标题
DOI：
10.1097/aud.0000000000001186
复制
发表时间：
2022-07-01
期刊：
影响因子：
3.7
通讯作者：
中科院分区：
文献类型：
--
作者：
听力正常的HIV阳性（HIV+）个体表现出中枢听觉处理缺陷，与HIV对照组相比，在噪音中言语感知的表现更差。HIV感染和治疗也与较低的神经认知筛查测试分数有关，表明潜在的中枢神经系统损伤。为了确定HIV+个体的中枢听觉处理缺陷与听觉处理相关的大脑皮层改变之间的关系，我们使用静息状态fMRI比较了有或没有噪音中语音感知困难的HIV+成人和年龄匹配的HIV阴性（HIV -）对照之间的听觉网络（AN）功能连接。根据噪声听力测试的语音识别阈值，将27例HIV阳性患者分为语音噪声感知异常组（HIV+SPabnl, 38.2±6.8岁，男11名，女2名）和无语音噪声感知异常组（HIV+SPabnl, 34.4±8.8岁，男14名）。同时纳入正常语音噪声感知的HIV组（HIV−，年龄31.3±5.2岁，男9名，女3名）。所有这些年轻人和中年人都有正常的周围听力测定。参与者使用静息状态功能磁共振成像（fMRI）进行研究。采用独立成分分析对AN进行鉴定。使用统计参数映射确定AN的组差异。与HIV -组相比，两个HIV+组AN部分的功能连通性（FC）都有所增加，包括颞上回、颞中回、边缘上回和罗兰底盖。与HIV+SPabnl组相比，HIV+SPabnl组在包括额下回和额中回在内的部分AN中表现出更高的FC，并在颞上回中表现出更低的FC。无论言语感知能力如何，颞叶的经典听觉区域都受到HIV的影响。在HIV+个体中增加的时间FC可能反映了功能补偿以实现正常的初级听觉。此外，与HIV+SPabnl组相比，HIV+SPabnl组的额叶FC增加表明，HIV感染的成年人在噪音中言语感知困难也影响到涉及高级认知能力的区域，这提供了与中央听觉处理缺陷与HIV相关的神经认知缺陷假设相一致的影像学证据。
HIV positive (HIV+) individuals with otherwise normal hearing ability show central auditory processing deficits as evidenced by worse performance in speech-in-noise perception compared to HIV− controls. HIV infection and treatment are also associated with lower neurocognitive screening test scores, suggesting underlying central nervous system damage. To determine how central auditory processing deficits in HIV+ individuals relate to brain alterations in the cortex involved with auditory processing, we compared auditory network (AN) functional connectivity between HIV+ adults with or without speech-in-noise perception difficulties and age-matched HIV negative (HIV−) controls using resting-state fMRI. Based on the speech recognition threshold of the hearing-in-noise test, twenty-seven HIV+ individuals were divided into a group with speech-in-noise perception abnormalities (HIV+SPabnl, 38.2 ± 6.8 years; 11 males and 2 females) and one without (HIV+SPnl 34.4 ± 8.8 years; 14 males). An HIV-group with normal speech-in-noise perception (HIV−, 31.3 ± 5.2 years; 9 males and 3 females) was also enrolled. All of these younger and middle-aged adults had normal peripheral hearing determined by audiometry. Participants were studied using resting-state fMRI. Independent component analysis was applied to identify the AN. Group differences in the AN were identified using statistical parametric mapping. Both HIV+ groups had increased functional connectivity (FC) in parts of the AN including the superior temporal gyrus, middle temporal gyrus, supramarginal gyrus, and Rolandic operculum compared to the HIV− group. Compared to the HIV+SPnl group, the HIV+SPabnl group showed greater FC in parts of the AN including the inferior frontal and middle frontal gyrus combined with reduced FC in the superior temporal gyrus. The classical auditory areas in the temporal lobe are affected by HIV regardless of speech perception ability. Increased temporal FC in HIV+ individuals might reflect functional compensation to achieve normal primary auditory perception. Furthermore, increased frontal FC in the HIV+SPabnl group compared to the HIV+SPnl group suggest that speech-in-noise perception difficulties in HIV− infected adults also affect areas involved in higher-level cognitive ability, providing imaging evidence consistent with the hypothesis that central auditory processing deficits are related to HIV-related neurocognitive deficits.