EFFECTS OF DIFFERENT DOSES OF FISH-OIL ON RECTAL CELL-PROLIFERATION IN PATIENTS WITH SPORADIC COLONIC ADENOMAS
EFFECTS OF DIFFERENT DOSES OF FISH-OIL ON RECTAL CELL-PROLIFERATION IN PATIENTS WITH SPORADIC COLONIC ADENOMAS
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DOI：
10.1016/0016-5085(94)90811-7
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发表时间：
1994-12-01
期刊：
影响因子：
29.4
通讯作者：
GASBARRINI, G
中科院分区：
文献类型：
--
作者：
ANTI, M;ARMELAO, F;GASBARRINI, G
背景/目的：补充鱼油可以减少散发性结直肠腺瘤患者平坦直肠粘膜的细胞动力学异常。本研究试图确定鱼油补充剂的最佳剂量，并评估其在长期给药过程中的持续作用。方法：在一项双盲研究中，60名散发性腺瘤患者每天接受2.5、5.1或7.7 g鱼油或安慰剂治疗30天。在补充前和补充后收集的扁平直肠粘膜活检标本中计算[H-3]胸苷放射自显影标记指数。在随后的研究中，15名息肉患者每天接受2.5克鱼油。在补充6个月之前、期间和之后，评价了消化参数、粘膜脂肪酸、粘膜和血浆α-生育酚水平。结果如下：在所有给药组中，平均增殖指数和粘膜花生四烯酸水平显著降低（程度相似），而粘膜二十碳五烯酸和二十二碳六烯酸水平升高。仅在基线模式异常的患者中观察到增殖显著降低。这些影响在长期低剂量治疗期间持续存在。治疗1个月后，观察到粘膜（而非血浆）α-生育酚水平一过性降低。副作用是微不足道的。结论：低剂量鱼油补充剂对与结肠癌风险增加相关的异常直肠增殖模式具有短期和长期正常化作用。
Background/Aims: Fish oil supplementation can reduce cytokinetic anomalies in the flat rectal mucosa of patients with sporadic colorectal adenoma. This study attempted to identify an optimum dose for fish oil supplementation and evaluate the persistence of its effects during long-term administration. Methods: In a double-blind study, 60 patients with sporadic adenomas received 2.5, 5.1, or 7.7 g of fish oil per day or placebo for 30 days. [H-3]thymidine autoradiographic labeling indices were calculated in flat rectal mucosal biopsy specimens collected before and after supplementation. In a subsequent study, 15 patients with polyps received 2.5 g of fish oil per day. Proliferative parameters, mucosal fatty acids, and mucosal and plasma alpha-tocopherol levels were evaluated before, during, and after 6 months of supplementation. Results: Mean proliferative indices and mucosal arachidonic acid levels decreased significantly (and to similar degrees) in all treated groups, whereas mucosal eicosapentaenoic and docosahexaenoic acid levels increased. Significantly reduced proliferation was observed only in patients with abnormal baseline patterns. These effects persisted during long-term, low-dose treatment. A transient reduction in mucosal (but not plasma) alpha-tocopherol levels was observed after 1 month of treatment. Side effects were insignificant. Conclusions: Low-dose fish oil supplementation has short-term and long-term normalizing effects on the abnormal rectal proliferation patterns associated with increased colon cancer risk.