The parahippocampal cortex mediates spatial and nonspatial associations
The parahippocampal cortex mediates spatial and nonspatial associations
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DOI：
10.1093/cercor/bhl078
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发表时间：
2007-07-01
期刊：
影响因子：
3.7
通讯作者：
Bar, M.
中科院分区：
文献类型：
--
作者：
Aminoff, E.;Gronau, N.;Bar, M.
海马旁皮质（PHC）参与了位置相关信息的加工。它也与情景记忆有关，即使是与独特地点无关的项目。同一个皮层区域怎么可能调节如此不同的认知过程呢？这两个过程依赖于上下文关联，因此，我们建议，PHC不应被视为专门用于分析与地点相关的信息，或作为单独处理情节记忆，而是更普遍地发挥核心作用，在上下文关联处理。为了验证这个提议，我们创建了一个新的学习范式，在无意义的视觉模式之间形成新的关联。这些新的关联是为了模拟空间或非空间背景而创建的。空间和非空间联想激活的PHC比非上下文项目。此外，来自空间背景的项目激活了PHC的后部，而来自非空间背景的项目激活了PHC的前部。因此，我们表明，PHC起着一般的处理上下文关联的作用，这些协会不限于空间信息。通过相应地修改对初级保健功能的现有看法，可以在一个总体框架下调和激活初级保健功能的看似矛盾的过程。
The parahippocampal cortex (PHC) has been implicated in the processing of place-related information. It has also been implicated in episodic memory, even for items that are not related to unique places. How could the same cortical region mediate such seemingly different cognitive processes? Both processes rely on contextual associations, and we therefore propose that the PHC should be viewed not as exclusively dedicated for analyzing place-related information, or as solely processing episodic memories, but instead as more generally playing a central role in contextual associative processing. To test this proposal, we created a novel learning paradigm to form new associations among meaningless visual patterns. These new associations were created to emulate either spatial or nonspatial contexts. Both spatial and nonspatial associations activated the PHC more than noncontextual items. Moreover, items from spatial contexts activated the posterior part of the PHC, whereas items from nonspatial contexts activated the anterior PHC. Therefore, we show that the PHC plays a role of processing contextual associations in general, and that these associations are not restricted to spatial information. By modifying the existing view of the PHC function accordingly, the seemingly contradicting processes that activate it can be reconciled under one overarching framework.