Physical activity and risk of cognitive impairment and dementia in elderly persons
Physical activity and risk of cognitive impairment and dementia in elderly persons
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DOI：
10.1001/archneur.58.3.498
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发表时间：
2001-03-01
影响因子：
--
通讯作者：
Rockwood, K
中科院分区：
文献类型：
--
作者：
Laurin, D;Verreault, R;Rockwood, K
背景：痴呆症是常见的，昂贵的，与年龄高度相关。很少有人注意到可改变的生活习惯的识别，以预防其prevention.Objective：探讨体力活动与认知障碍和痴呆风险之间的关系。数据来自于9008名随机选择的65岁或以上的男性和女性的社区样本，他们在1991-1992年加拿大健康与老龄化研究中进行了评估，一项关于痴呆症的前瞻性队列研究在6434例基线认知正常的合格受试者中，4615例完成了5年随访。在研究的两个波进行筛选和临床评价。在1996-1997年，3894人仍然没有认知障碍，436人被诊断为有认知障碍-无痴呆，285人被诊断为有痴呆。主要结果测量：在基线时，根据体力活动水平，发生认知障碍和痴呆。与不锻炼相比，体育锻炼与认知障碍、阿尔茨海默病和任何类型的痴呆症的风险较低有关。观察到随着体力活动的增加而增加保护的显著趋势。高水平的体力活动与认知障碍的风险降低有关（年龄、性别和教育调整的比值比，0.58; 95%置信区间，0.41-0.83），阿尔茨海默病（比值比，0.50; 95%置信区间，0.28-0.90），和任何类型的痴呆结论：有规律的体力活动是老年人认知功能减退和痴呆的重要保护因素。
Context: Dementia is common, costly, and highly age related. Little attention has been paid to the identification;of modifiable lifestyle habits for its prevention.Objective: To explore the association between physical activity and the risk of cognitive impairment and dementia.Design, Setting, and Subjects: Data come from a community sample of 9008 randomly selected men and women 65 years or older, who were evaluated in the 1991-1992 Canadian Study of Health and Aging, a prospective cohort study of dementia. Of the 6434 eligible subjects who were cognitively normal at baseline, 4615 completed a 5-year follow-up. Screening and clinical evaluations were done at both waves of the study. In 1996-1997, 3894 remained without cognitive impairment, 436 were diagnosed as having cognitive impairment-no dementia, and 285 were diagnosed as having dementia.Main Outcome Measure: Incident cognitive impairment and dementia by levels of physical activity at baseline.Results: Compared with no exercise, physical activity was associated with lower risks of cognitive impairment, Alzheimer disease, and dementia of any type. Significant trends for increased protection with greater physical activity were observed. High levels of physical activity were associated with reduced risks of cognitive impairment (age-, sex-, and education-adjusted odds ratio, 0.58; 95% confidence interval, 0.41-0.83), Alzheimer disease (odds ratio, 0.50; 95% confidence interval, 0.28-0.90), and dementia of any type (odds ratio, 0.63; 95% confidence interval, 0.40-0.98).Conclusion: Regular physical activity could represent an important and potent protective factor for cognitive decline and dementia in elderly persons.