Substrate-Induced Covalent Assembly of a Chemzyme and Crystallographic Characterization of a Chemzyme-Substrate Complex
Substrate-Induced Covalent Assembly of a Chemzyme and Crystallographic Characterization of a Chemzyme-Substrate Complex
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DOI：
10.1021/ja1070224
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发表时间：
2010-10-20
影响因子：
15
通讯作者：
Wulff, William D.
中科院分区：
文献类型：
--
作者：
Hu, Gang;Gupta, Anil K.;Wulff, William D.
描述了一种底物诱导的高度组织化的化学酶的共价组装，该化学酶已知在催化不对称氮丙啶化和氮杂狄尔斯-阿尔德反应中均有效，并且从中获得的信息导致了有效的一锅氮丙啶化方案。通过 X 射线衍射分析阐明了两种 chemzyme-iminium 复合物的晶体结构，该分析为底物与 chemzyme 的结合提供了重要的见解。
A substrate induced covalent assembly of a highly organized chemzyme known to be effective in both catalytic asymmetric aziridination and aza Diels-Alder reactions is described and the information gained from which led to an efficient one-pot aziridination protocol. The crystal structures of two chemzyme-iminium complexes were elucidated by X-ray diffraction analysis that provides critical insights into the binding of the substrates with the chemzyme.