Functioning in middle aged and older patients with schizophrenia and depressive symptoms: relationship to psychopathology.
Functioning in middle aged and older patients with schizophrenia and depressive symptoms: relationship to psychopathology.
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DOI：
10.1097/jgp.0b013e31816ff746
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发表时间：
2008-08
期刊：
影响因子：
--
通讯作者：
Zisook S
中科院分区：
文献类型：
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作者：
Kasckow J;Patterson T;Fellows I;Golshan S;Solorzano E;Mohamed S;Zisook S
抑郁症状在中老年精神分裂症患者中很常见，作者假设这些患者的功能较差与精神病理学较差有关。门诊精神分裂症患者年龄≥40岁，亚综合征抑郁，汉密尔顿抑郁量表评分≥8分。排除痴呆、2个月躁狂或重度抑郁或1个月活性物质滥用/依赖。作者进行了基于表现的功能评估、精神分裂症阳性和阴性症状量表[PANSS]和卡尔加里抑郁评定量表。PANSS（−）评分与UCSD基于表现技能的评估、社交技能表现评估和药物管理能力评估总错误（MMAA）评分呈负相关。数字符号评分是MMAA和PANSS（-）评分之间关系的调节因子。阴性症状与功能相关。负性症状与药物治疗的关系在加工速度快的被试中似乎减弱。
Depressive symptoms are common in middle aged and older patients with schizophrenia, The authors hypothesized that worse functioning in these patients would be associated with worse psychopathology. Outpatients with schizophrenia were ≥40 years old with subsyndromal depression and Hamilton Depression Rating Scale Scores of ≥8. Exclusions were dementia, two months of either mania or major depression or 1 month active substance abuse/dependence. The authors administered performance based functional assessments, the Positive and Negative Syndrome Scale of Schizophrenia [PANSS], and Calgary Depression Rating Scale. PANSS (−) scores were negatively correlated with the UCSD Performance Skills Based Assessment, Social Skills Performance Assessment and Medication Management Ability Assessment total error (MMAA) scores. Digit symbol scores served as a moderator of the relationship between MMAA and PANSS (−) scores. Negative symptoms were associated with functioning. The relationship between negative symptoms and medication etrors seem to weaken in subjects with quicker processing speed.