Effect of acute hypohydration on glycemic regulation in healthy adults: a randomized crossover trial
Effect of acute hypohydration on glycemic regulation in healthy adults: a randomized crossover trial
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DOI：
10.1152/japplphysiol.00771.2018
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发表时间：
2019-02-01
影响因子：
3.3
通讯作者：
Betts, James A.
中科院分区：
文献类型：
--
作者：
Carroll, Harriet A.;Templeman, Iain;Betts, James A.
本研究的目的是研究水合状态对健康成人血糖调节的急性影响，并探讨其潜在机制。在这项随机交叉试验中，16名健康成年人（8名男性，8名女性）在试验前标准化4天后接受了口服葡萄糖耐量试验（OGTT）。OGTT前一天，参与者在热帐篷中脱水1小时，随后进行液体限制（HYPO）或补充（RE）。第二天，进行OGTT，测量代谢率，并进行OGTT前后肌肉活检。在干预前后进行外围定量计算机断层扫描，以推断细胞体积的变化。HYPO（而非RE）诱导了1.9% （SD 1.2）的体重损失，2.9% （SD 2.7）的细胞体积减少，尿液水化指标、血清渗透压和血浆copeptin浓度升高(均为P
The aim of this study was to investigate the acute effect of hydration status on glycemic regulation in healthy adults and explore underlying mechanisms. In this randomized crossover trial, 16 healthy adults (8 men, 8 women) underwent an oral glucose tolerance test (OGTT) when hypohydrated and rehydrated after 4 days of pretrial standardization. One day before OGTT, participants were dehydrated for 1 h in a heat tent with subsequent fluid restriction (HYPO) or replacement (RE). The following day, an OGTT was performed with metabolic rate measurements and pre- and post-OGTT muscle biopsies. Peripheral quantitative computer tomography thigh scans were taken before and after intervention to infer changes in cell volume. HYPO (but not RE) induced 1.9% (SD 1.2) body mass loss, 2.9% (SD 2.7) cell volume reduction, and increased urinary hydration markers, serum osmolality, and plasma copeptin concentration (all P