Can the wound healing response of human skin be modulated after laser treatment and the effects of exposure extended? Implications on the combined use of the pulsed dye laser and a topical angiogenesis inhibitor for treatment of port wine stain birthmarks
Can the wound healing response of human skin be modulated after laser treatment and the effects of exposure extended? Implications on the combined use of the pulsed dye laser and a topical angiogenesis inhibitor for treatment of port wine stain birthmarks
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DOI：
10.1002/lsm.20599
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发表时间：
2008-01-01
影响因子：
2.4
通讯作者：
Nelson, J. Stuart
中科院分区：
文献类型：
--
作者：
Phung, Thuy L.;Oble, Darryl A.;Nelson, J. Stuart
鲜红斑痣(PWS)，又称鲜红斑痣，是一种先天性皮肤血管畸形，累及毛细血管后小静脉，使皮肤产生浅粉色至深红紫色的变色。对于PWS的发展，最可能的假设是周围的神经元缺乏或缺乏调节通过扩张的毛细血管后小静脉的血流。因此，血管无法正常收缩并保持永久扩张。PWS的标准治疗方法是脉冲染料激光(PDL)，它诱导表面下靶向血管的光凝，而不会导致正常上皮的热损伤。通过选择性光热分解，PDL发出的光优先被PWS血管中的血红蛋白吸收，血红蛋白是血液中的主要发色团，在转化为热后，它会导致热损伤和血栓形成[1]。此后，残留的血液和血管壁成分在皮肤内被吸收，并被真皮胶原蛋白取代。
Port wine stain (PWS), also called nevus flammeus, is a congenital, cutaneous vascular malformation involving post-capillary venules which produce a light pink to dark-red-violet discoloration of the skin. The most likely hypothesis for the development of PWS is the deficiency or absence of surrounding neurons regulating blood flow through the ectatic postcapillary venules. As a result, the blood vessels are unable to constrict normally and remain permanently dilated.The standard treatment for PWS is the pulsed dye laser (PDL), which induces photocoagulation of the subsurface-targeted blood vessels without inducing thermal damage in the normal overlying epidermis. Through selective photo-thermolysis, light emitted by the PDL is preferentially absorbed by hemoglobin, a major chromophore in blood, in the PWS blood vessels where, after being converted to heat, it causes thermal damage and thrombosis [1]. Thereafter, remnants of the blood and vascular wall components are assimilated within the skin and replaced by dermal collagen.