Childhood risk factors predict adult risk associated with subclinical cardiovascular disease: The Bogalusa Heart Study
Childhood risk factors predict adult risk associated with subclinical cardiovascular disease: The Bogalusa Heart Study
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DOI：
10.1016/s0002-9149(02)02953-3
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发表时间：
2002-11-21
影响因子：
2.8
通讯作者：
Berenson, GS
中科院分区：
文献类型：
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作者：
Berenson, GS
心血管危险因素始于儿童期，可预测成年期的心血管风险。Bogalusa心脏研究的观察结果表明，早期临床危险因素与动脉粥样硬化的主动脉和冠状血管的解剖变化以及高血压相关的心脏和肾脏变化具有重要的相关性。这些观察结果通过颈动脉内膜中膜厚度（IMT）的回声多普勒研究得到了扩展。在20-38岁的年轻人中，危险因素与IMT密切相关，并且随着危险因素数量的增加，明显增加。更广泛的变化似乎发生在鳞茎或分叉区。这个区域可能是疾病的早期标志。观察年轻人的危险因素和对心血管系统结构变化的非侵入性研究对心脏病专家的预防具有重要意义。(C) 2002年由摘录医学公司。
Cardiovascular risk factors begin in childhood and are predictive of cardiovascular risk in adulthood. Observations in the Bogalusa Heart Study have shown an important correlation of clinical risk factors in early life with anatomic changes in the aorta and coronary vessels with atherosclerosis and cardiac and renal changes related to hypertension. These observations have been extended by echo Doppler studies of carotid artery intima media thickness (IMT). A close association of risk factors in young adults, 20-38 years of age, occurs with IMT, and a marked increase is noted as numbers of risk factors increase. More extensive changes seem to occur in the bulb or bifurcation area. This area may be an earlier marker of disease. Observations of risk factors in young individuals and noninvasive studies of structural changes of the cardiovascular system have strong implications for prevention by cardiologists. (C) 2002 by Excerpta Medica, Inc.