Gender-specific action of thyrotropin-releasing hormone in the mammalian spinal cord.
Gender-specific action of thyrotropin-releasing hormone in the mammalian spinal cord.
复制标题
哺乳动物脊髓中促甲状腺素释放激素的性别特异性作用。
DOI：
10.1096/fasebj.1.6.3119415
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发表时间：
1987
期刊：
影响因子：
--
通讯作者：
Warnick,JE
中科院分区：
文献类型：
--
作者：
Deshpande,SB;Pilotte,NS;Warnick,JE
Thyrotropin‐releasing hormone (TRH) potentiated the monosynaptic reflex in isolated spinal cords obtained from 7‐ to 9‐day‐old rats. A concentration‐dependent increase in the monosynaptic reflex was observed in spinal cords obtained from male but not from female or castrated male rats. In contrast, the magnitude of potentiation in cords from ovariectomized control female rats and in ovariectomized female rats treated with testosterone approached that seen in intact males. The results provide evidence that gender plays a prominent role in the variability of response both of humans with amyotrophic lateral sclerosis and of animal tissues to TRH. Furthermore, exposure to androgen during the neonatal period may determine the responsiveness of motoneurons to TRH. Thus the use of TRH in the treatment of amyotrophic lateral sclerosis may be more effective in males than in females.— Deshpande, S. B.; Pilotte, N. S.; Warnick, J. E. Gender‐specific action of thyrotropin‐releasing hormone in the mammalian spinal cord.FASEB J.1: 478‐482; 1987.
