Linking pediatric obesity to subclinical alterations in cardiac structure and function.
Linking pediatric obesity to subclinical alterations in cardiac structure and function.
复制标题
将儿童肥胖与心脏结构和功能的亚临床改变联系起来。
DOI：
10.1016/j.jcmg.2014.09.006
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Marx,GeraldR
中科院分区：
文献类型：
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作者：
Zachariah,JustinP;Ingul,CharlotteB;Marx,GeraldR
在本期iJACC中，Manger et al. (1)详细说明儿童肥胖的临床前超声心动图相关性。特别是，研究人员发现肥胖儿童左心室（LV）几何结构改变与向心性重塑和明显肥大一致。这些肥胖儿童也有功能改变，包括减少纵向应变，周向应变，和异常多普勒舒张功能参数。这项研究有助于拓宽儿童肥胖与临床前解剖和功能性心血管变化之间的联系，这些变化是未来心血管健康状况不佳的基础。人们普遍认为，肥胖相关心血管疾病（CVD）风险的很大一部分是通过并发的经典CVD风险因素介导的（2）。尽管最近的报告表明，儿童肥胖趋势已经出现了适当的减速，但仍然有大量儿童超重（3）。不幸的是，早期肥胖实际上可以预测未来的CVD和过早死亡（4，5）。支持这些观察结果的数据将早期超重与动脉粥样硬化中介联系起来，如高血压和高胆固醇的患病率较高;未来
In this issue of iJACC, Manger et al.(1) detail preclinical echocardiographic correlates of obesity in children. Specifically, the investigators found that obese children had left ventricular (LV) geometric alterations consistent with concentric remodeling and frank hypertrophy. These obese children also had functional alterations, including reduced longitudinal strain, circumferential strain, and abnormal Doppler diastolic function parameters. This study contributes to a broadening avenue connecting pediatric obesity to pre-clinical anatomic and functional cardiovascular changes that are the underpinnings of future poor cardiovascular health.There is general agreement that a substantial portion of obesity-related cardiovascular disease (CVD) risk is mediated through concurrent classic CVD risk factors (2). Although recent reports suggest that there has been a felicitous deceleration in pediatric obesity trends, there are still a large number of children carrying excess weight (3). Unfortunately, early life obesity actually does predict future CVD and premature mortality (4, 5). Supporting these observations are data connecting excess weight in early life to atherosclerotic intermediaries such as higher prevalence of high blood pressure and cholesterol; future