Cerebral Amyloid and Cognition after Surgery: Reply.
Cerebral Amyloid and Cognition after Surgery: Reply.
复制标题
脑淀粉样蛋白与手术后认知：回复。
DOI：
10.1097/aln.0000000000002784
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发表时间：
2019
期刊：
影响因子：
8.8
通讯作者：
Mathew,JosephP
中科院分区：
文献类型：
--
作者：
Klinger,RebeccaY;Mathew,JosephP
We thank Dr. Meng and colleagues for their letter to the editor regarding our study exploring cerebral β-amyloid deposition and cognition after cardiac surgery. 1 The authors have pointed out several important limitations of our study, which we have already acknowledged in the original publication.Certainly, postoperative cognitive dysfunction has a complex pathophysiological basis without a clear etiology in current understanding. Our study was designed to explore one potential mechanism contributing to cognitive decline after cardiac surgery, while adjusting for other well-established predictors. However, as we acknowledged, our sample size was limited and only designed to explore the relationship between global cortical amyloid deposition, using the novel positron emission tomography (PET) β-amyloid tracer 18F-florbetapir, and cognitive change after cardiac surgery. We do not draw any definitive conclusions from our results, but rather present them to add to the discussion in the field of postoperative cognitive decline (POCD) research and to potentially generate hypotheses and offer methodologies for future investigations. Limiting analyses to subjects with normal amyloid burden, as suggested by Meng and colleagues, also seems pointless as the effect of abnormal amyloid deposition could not then be assessed.
