The effect of conjugated linoleic acid, a natural trans fat from milk and meat, on human blood pressure: results from a randomized crossover feeding study
The effect of conjugated linoleic acid, a natural trans fat from milk and meat, on human blood pressure: results from a randomized crossover feeding study
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DOI：
10.1038/jhh.2010.132
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发表时间：
2012-02-01
影响因子：
2.7
通讯作者：
Brouwer, I. A.
中科院分区：
文献类型：
--
作者：
Engberink, M. F.;Geleijnse, J. M.;Brouwer, I. A.
顺-9，反-11共轭亚油酸(CLA)是一种天然的反式脂肪酸，主要限于反式脂肪，并在食物和补充剂中消费。它在血压调节中的作用尚不清楚。我们比较了顺-9，反-11共轭亚油酸和油酸对血压的影响。61名健康志愿者按随机顺序依次饲喂3种饮食，共9周。除了7%的能量(10MJday(-1)日粮中18.9g)由油酸、工业反式脂肪酸或顺-9、反式-11CLA提供外，其余均相同。在每个干预期结束时，我们分别在两天测量血压。基线时，平均血压为113.8+/-14.4 mm Hg收缩压和66.3+/-9.6 mm Hg舒张压。共轭亚油酸饮食与油酸饮食相比，收缩压和舒张压的影响分别为0.11 mm Hg(95%可信区间：-1.27，1.49)和-0.45 mm Hg(-1.63，0.73)。工业反式脂肪酸饮食后，与油酸饮食相比，收缩压和舒张压分别为1.13 mm Hg(-0.25，2.51)和-0.44 mm Hg(-1.62，0.73)。我们的研究表明，短期高摄入顺式-9，反式-11共轭亚油酸对健康志愿者的血压没有影响。《人类高血压杂志》(2012年)第26期，第127-132期；doi：10.1038/jhh.2010.132；2011年1月27日在线发表
Cis-9, trans-11 conjugated linoleic acid (CLA) is a natural trans fatty acid that is largely restricted to ruminant fats and consumed in foods and supplements. Its role in blood pressure (BP) regulation is still unclear. We examined the effect of cis-9, trans-11 CLA on BP compared with oleic acid. A total of 61 healthy volunteers were sequentially fed each of 3 diets for 3 weeks, in random order, for a total of 9 weeks. The diets were identical except for 7% of energy (18.9 g in a diet of 10MJday(-1)) that was provided either by oleic acid, by industrial trans fatty acids or by cis-9, trans-11 CLA. We measured BP on two separate days at the end of each intervention period. At baseline, mean BP was 113.8 +/- 14.4mmHg systolic and 66.3 +/- 9.6mmHg diastolic. The effect of the CLA diet compared with the oleic acid diet was 0.11mmHg (95% confidence interval: -1.27, 1.49) systolic and -0.45mmHg (-1.63, 0.73) diastolic. After the industrial trans fatty acid diet, the effect was 1.13mmHg (-0.25, 2.51) systolic and -0.44mmHg (-1.62, 0.73) diastolic compared with the oleic acid diet. Our study suggests that short-term high intakes of cis-9, trans-11 CLA do not affect BP in healthy volunteers. Journal of Human Hypertension (2012) 26, 127-132; doi:10.1038/jhh.2010.132; published online 27 January 2011