Tumour ADC measurements in rectal cancer: effect of ROI methods on ADC values and interobserver variability.
Tumour ADC measurements in rectal cancer: effect of ROI methods on ADC values and interobserver variability.
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DOI：
10.1007/s00330-011-2220-5
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发表时间：
2011-12
影响因子：
5.9
通讯作者：
Beets-Tan RG
中科院分区：
文献类型：
--
作者：
Lambregts DM;Beets GL;Maas M;Curvo-Semedo L;Kessels AG;Thywissen T;Beets-Tan RG
评估感兴趣区域 (ROI) 大小和位置对局部晚期直肠癌 (LARC) 患者肿瘤 ADC 测量和观察者间变异的影响。回顾性纳入 46 名 LARC 患者。患者在放化疗 (CRT) 之前和放化疗后 6-8 周接受了 MRI，包括 DWI (b0,500,1000)。两名读数器根据三种 ROI 方案（全体积、单切片或小固体样本）测量平均肿瘤 ADC（CRT 前和 CRT 后）。比较了这三种方案在 ADC、SD 和观察者间变异性（以组内相关系数衡量；ICC）方面的差异。 CRT 前全体积 ROI 的 ICC 非常好（0.91），而 CRT 后则良好（0.66）。单切片 ROI 的 ICC 分别为 0.53 和 0.42，而样本 ROI 的 ICC 分别为 0.60 和 0.65。样本 ROI 的 CRT 前 ADC 显着低于全体积或单切片 ROI。 CRT 后，全体积 ROI 与单切片或样本 ROI 之间分别没有显着差异。全体积和单切片 ROI 的 SD 明显大于样本 ROI。 ROI 大小和位置对肿瘤 ADC 值和观察者间变异性有相当大的影响。 CRT 后观察者间的变异性更严重。从整个肿瘤体积获得的 ADC 可提供最具重复性的结果。 要点 • ROI 大小和位置影响直肠癌中的肿瘤 ADC 测量 • ROI 大小和位置影响肿瘤 ADC 测量的观察者间变异性 • 整个肿瘤体积的 ADC 测量可提供最具可重复性的结果 • 肿瘤 ADC 测量在放化疗之前而不是之后更具可重复性 • 使用 ADC 作为肿瘤生物标志物时，应考虑 ROI 大小和位置引起的变化 肿瘤反应
To assess the influence of region of interest (ROI) size and positioning on tumour ADC measurements and interobserver variability in patients with locally advanced rectal cancer (LARC). Forty-six LARC patients were retrospectively included. Patients underwent MRI including DWI (b0,500,1000) before and 6–8 weeks after chemoradiation (CRT). Two readers measured mean tumour ADCs (pre- and post-CRT) according to three ROI protocols: whole-volume, single-slice or small solid samples. The three protocols were compared for differences in ADC, SD and interobserver variability (measured as the intraclass correlation coefficient; ICC). ICC for the whole-volume ROIs was excellent (0.91) pre-CRT versus good (0.66) post-CRT. ICCs were 0.53 and 0.42 for the single-slice ROIs versus 0.60 and 0.65 for the sample ROIs. Pre-CRT ADCs for the sample ROIs were significantly lower than for the whole-volume or single-slice ROIs. Post-CRT there were no significant differences between the whole-volume ROIs and the single-slice or sample ROIs, respectively. The SDs for the whole-volume and single-slice ROIs were significantly larger than for the sample ROIs. ROI size and positioning have a considerable influence on tumour ADC values and interobserver variability. Interobserver variability is worse after CRT. ADCs obtained from the whole tumour volume provide the most reproducible results. Key Points • ROI size and positioning influence tumour ADC measurements in rectal cancer • ROI size and positioning influence interobserver variability of tumour ADC measurements • ADC measurements of the whole tumour volume provide the most reproducible results • Tumour ADC measurements are more reproducible before, rather than after, chemoradiation treatment • Variations caused by ROI size and positioning should be taken into account when using ADC as a biomarker for tumour response
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