Hypothesis: joints can heal.
Hypothesis: joints can heal.
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假设：关节可以愈合。
DOI：
10.1016/0049-0172(84)90031-3
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发表时间：
1984
影响因子：
5
通讯作者：
Burr,DB
中科院分区：
文献类型：
--
作者：
Radin,EL;Burr,DB
虽然软骨具有有限的内在修复能力，但如果存在适当的条件，软骨的外在细胞可以提供修复机制。产生的新的软骨样物质，尽管在组织学或生物化学上与成熟的透明关节软骨不同，但在许多情况下仍然可以允许正常的关节功能并防止进一步的关节退化。证据表明，关节愈合的结果是建立一个细胞来源，正常化关节压力，并鼓励关节运动。围绕关节是否可以愈合的问题的大部分争议都是由于未能将关节功能而不是软骨外观视为愈合过程中最重要的组成部分，以及未能理解机械因素在促进这种反应中所起的重要作用。
Although cartilage has a limited capacity for intrinsic repair, cells extrinsic to the cartilage can provide a mechanism for repair if the proper conditions exist. The new chondroid material produced, although not histologically or biochemically identical to mature hyaline articular cartilage, can nevertheless in many circumstances permit normal joint function and prevent further joint deterioration. The evidence suggests that joint healing results from establishing a source of cells, normalizing joint pressures, and encouraging joint motion. Much of the controversy surrounding the question of whether joints can heal results from a failure to view joint function, rather than cartilage appearance, as the most important component of the healing process, and to appreciate the significant role played by mechanical factors in promoting this response.