Urinary angiotensinogen excretion level is associated with elevated blood pressure in the normotensive general population.
Urinary angiotensinogen excretion level is associated with elevated blood pressure in the normotensive general population.
复制标题
尿血管紧张素原排泄水平与血压正常的一般人群的血压升高相关。
DOI：
10.1093/ajh/hpy020
复制
发表时间：
2018
期刊：
影响因子：
3.2
通讯作者：
Mori T
中科院分区：
文献类型：
--
作者：
Sato E;Wang AY;Satoh M;Nishikiori Y;Oba-Yabana I;Yoshida M;Sato H;Ito S;Hida W;Mori T
研究背景炎症、肾内肾素-血管紧张素系统（RAS）激活、氧化应激和羰基应激被认为在控制血压中起着重要作用。然而，鲜为人知的是，肾RAS激活，羰基应激，血压elevation. METHODS之间的关联我们评估血压升高和肾RAS活性或羰基应激在一般人群（N= 355）在日本之间的关系。为了尽量减少降压药物治疗的影响，我们将参与者分为3组（血压正常，高血压非药物治疗，高血压药物治疗）。肾内RAS活性和羰基应激分别由尿血管紧张素原（AGT）和羰基化合物排泄水平指示。使用逐步多元回归分析，我们发现，尿AGT排泄水平与血压升高密切相关，与炎症，氧化应激和羰基应激标志物相比，在所有组中。仅在高血压未用药组中，尿羰基化合物排泄量与血压显著相关。此外，这些参与者的血压显著升高，尿AGT和羰基化合物水平都很高。尿AGT排泄水平与血压升高在血压正常的人，和不适当的肾RAS活性和羰基应激独立的高血压的发展作出了贡献。结论这些研究结果表明，RAS激活，特别是肾RAS激活发挥了根本性的作用，在一般人群中的高血压的发病机制。
BACKGROUNDInflammation, intrarenal renin–angiotensin system (RAS) activation, oxidative stress, and carbonyl stress have been postulated to play a fundamental role in controlling blood pressure. However, little is known about the association among renal RAS activation, carbonyl stress, and blood pressure elevation.METHODSWe evaluated the relationship between blood pressure elevation and either renal RAS activity or carbonyl stress in the general population (N= 355) in Japan. To minimize the effect of antihypertensive drug therapy, we divided participants into 3 groups (normotensive, hypertensive-with-non-medication, and hypertensive-with-medication). Intrarenal RAS activity and carbonyl stress were indicated by the urinary angiotensinogen (AGT) and carbonyl compound excretion levels, respectively.RESULTSThe urinary AGT and carbonyl compound excretion levels were significantly associated with blood pressure. Using a stepwise multiple regression analysis, we found that the urinary AGT excretion levels were strongly associated with blood pressure elevation, compared with inflammation, oxidative stress, and carbonyl stress markers, in all groups. Urinary carbonyl compound excretion was significantly associated with blood pressure in only the hypertensive-without-medication group. Furthermore, blood pressure was significantly increased in these participants, and both the urinary AGT and carbonyl compound levels were high. The urinary AGT excretion levels were strongly associated with elevated blood pressure in normotensive people, and inappropriate renal RAS activity and carbonyl stress independently contributed to the development of hypertension.CONCLUSIONSThese findings suggest that RAS activation, particularly renal RAS activation exert a fundamental role in the pathogenesis of hypertension in the general population.